Digital technologies are being introduced in museums and other informal learning environments alongside more traditional interpretive and communication media. An increasing number of studies has proved the potential of digitallymediated cultural heritage experiences. However, there is still a lot of controversy as to the advantages and disadvantages of introducing the digital into museum settings, primarily related to the risks and investment in terms of time, human and financial resources required. This work introduces the MUSETECH model, a comprehensive framework for evaluating museum technology before and after its introduction into a museum setting. One of the unique features of our framework is to consider the evaluation of digital technologies from three different perspectives: the perspective of the cultural heritage professional, the perspective of the cultural heritage institution and the perspective of the museum visitor. The framework benefited from an extensive review of the current state of the art and from inputs from cultural heritage professionals, designers and engineers. MUSETECH can be used as a tool for reflection, before, during and after introducing novel digital media resources. The model covers technologies as diverse as mobile museum guides, Augmented and Virtual Reality applications, hands-on museum interactives, edutainment applications, digitally-mediated tangible and embodied experiences or online approaches used for museum education and learning.