Methodology for sample preparation and size measurement of commercial ZnO nanoparticles

Lu, Pei-Jia; Fu, Wei‐En; Huang, Shou-Chieh; Lin, Chin-Yuan; Ho, Mei‐Lin; Chen, Yu-Pen; Cheng, Hwei‐Fang

doi:10.1016/j.jfda.2017.07.004

Cited by 61 publications

(20 citation statements)

References 16 publications

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“…For zeta potential measurement, the electrophoretic light scattering technique was used. The results were interpreted using Malvern Zetasizer software [25,26].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug

et al. 2019

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Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities.

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“…For zeta potential measurement, the electrophoretic light scattering technique was used. The results were interpreted using Malvern Zetasizer software [25,26].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug

et al. 2019

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“…2. Characterize particle size using either dynamic light scattering 34 , 35 , single particle inductively coupled plasma mass spectrometry 36 , nanoparticle tracking analysis 37 , or transmission electron microscopy and surface charge as zeta potential using a zeta sizer 34 .…”

Section: Nm Preparationmentioning

confidence: 99%

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Chetwynd

Zhang

Faserl

et al. 2020

JoVE

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The adsorption of biomolecules from surrounding biological matrices to the surface of nanomaterials (NMs) to form the corona has been of interest for the past decade. Interest in the bio-nano interface arises from the fact that the biomolecular corona confers a biological identity to NMs and thus causes the body to identify them as "self". For example, previous studies have demonstrated that the proteins in the corona are capable of interacting with membrane receptors to influence cellular uptake and established that the corona is responsible for cellular trafficking of NMs and their eventual toxicity. To date, most research has focused upon the protein corona and overlooked the possible impacts of the metabolites included in the corona or synergistic effects between components in the complete biomolecular corona. As such, this work demonstrates methodologies to characterize both the protein and metabolite components of the biomolecular corona using bottom-up proteomics and metabolomics approaches in parallel. This includes an on-particle digest of the protein corona with a surfactant used to increase protein recovery, and a passive characterization of the metabolite corona by analyzing metabolite matrices before and after NM exposures. This work introduces capillary electrophoresis-mass spectrometry (CESI-MS) as a new technique for NM corona characterization. The protocols outlined here demonstrate how CESI-MS can be used for the reliable characterization of both the protein and metabolite corona acquired by NMs. The move to CESI-MS greatly decreases the volume of sample required (compared to traditional liquid chromatography-mass spectrometry (LC-MS) approaches) with multiple injections possible from as little as 5 µL of sample, making it ideal for volume limited samples. Furthermore, the environmental consequences of analysis

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“…Various aspects of particle size such as morphological (SEM) [8], size (DLS) [9] can be analyzed through advanced testing methods. Particle analysis, PSA and PSD analysis help in finding out measurement of average of mean size of particle in the specimen [10].…”

Section: Introductionmentioning

confidence: 99%

“…Nanoparticle dispersions are often polydisperse; there may be particles with a distribution of sizes and shapes rather than particles of a single size and shape. Dispersity is measure of heterogeneity of sizes of particles in a mixture [8]. PDI is calculated from a cumulants analysis of the DLS measured intensity.…”

Section: Introductionmentioning

confidence: 99%

Measurement of dispersion and homogeneity of functionalized graphene/CNT hybrid epoxy composite

Shukla

Sharma

2019

SN Appl. Sci.

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Fabrication of amine-functionalized multi-graphene layers and multi-walled carbon nanotube nanofillers (0.25, 0.50, 1 and 2 wt%) reinforced with epoxy resin has been successfully performed to obtain hybrid epoxy composite. Effect of filler ratio on dispersion and homogeneity of hybrid composite mixture is investigated. Particle size distribution (PSD) pattern and tensile properties of hybrid composite are correlated with the degree of dispersion. The PSD is performed by dynamic light scattering technique and image analysis method. Analyses of scanning electron microscopy images are performed using ImageJ software. The pattern of PSD for composites is found to be similar by both the methods. Hybrid composite reinforced with filler content 0.5 wt% shows best homogeneous mixture. The value of PDI is observed to be lowest by both PSD analysis methods which make agreement of results. Determination of tensile properties shows that maximum tensile stress of 49.91 MPa and elastic modulus of 2302 MPa are obtained for 0.5 wt% composite. Analysis of PSD of composite mixture provides a direction for selecting appropriate filler content and fabrication process.

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Methodology for sample preparation and size measurement of commercial ZnO nanoparticles

Cited by 61 publications

References 16 publications

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials

Measurement of dispersion and homogeneity of functionalized graphene/CNT hybrid epoxy composite

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