Methodology for the Study of Metabolism: Animal Models

Susa, John B.

doi:10.1007/978-1-4684-0400-5_3

Cited by 2 publications

(3 citation statements)

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“…The contribution of lactate to foetal metabolism amounts to one-third to one-half that of glucose in most species [17]. It is minimal in the human foetus but represents 25% of the carbon supply to foetal sheep [62]. According to Hay et al [36], 70% of the lactate utilised by the foetal lamb is oxidised.…”

Section: Lactatementioning

confidence: 99%

“…FFA are mainly incorporated into lipids and are therefore not a major energy source for foetal tissues [89,94]. In species with large lipid stores (humans, guineapigs), the transfer of FFA becomes inadequate near term and de novo lipid synthesis increases [62]. Unlike fatty acids, ketoacids could be an alternative fuel in the placenta and some foetal tissues of rats and humans and thus spare glucose [94].…”

Section: Fatty Acids Ketone Bodies and Glycerolmentioning

confidence: 99%

“…These exchanges depend on several aspects, mainly blood flow across the uterine and umbilical circulation, relative substrate concentration in 2 M.-C. Père Table I. Fat and glycogen stores in the neonates of several mammalian species (adapted from Susa [62] maternal and foetal blood, and placental permeability. Uterine blood flow steadily increases as pregnancy proceeds, which partly adapts the substrate supply to the requirements of the foetuses [3].…”

Section: Introductionmentioning

confidence: 99%

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Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species

Père

2003

Reprod. Nutr. Dev.

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-Several general features of nutrient uptake and utilisation by foetuses are similar among mammalian species. Nevertheless, there are also differences linked mainly to differences in placental permeability. Glucose and lactate are the main energetic substrates of the foetus. In normal conditions, the oxidation of carbohydrates accounts for about 75, 60 and 50% of oxygen uptake in the foetal pig, foal and lamb, respectively, and acetate accounts for about 10% in ruminants. Acidic amino acids are synthesised by the foetus, whereas neutral and basic amino acids are transported from the placenta. As shown by the high urea level in foetal blood, amino acids are partly involved in the oxidative metabolism of foetuses; their contribution is higher in ruminants than in humans, horses and pigs. Fatty acids cross the haemochorial placenta of rodents, rabbits and primates, and are incorporated into the foetal lipids, whereas their uptake by ruminant, pig and horse foetuses is very low.materno-foetal exchange / mammal / carbohydrate / fatty acid / amino acid

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Section: Lactatementioning

confidence: 99%