The efficient use of water resources is a subject of major concern for water utilities and authorities. One of the main challenges in improving the efficiency of drinking water networks is to minimize water loss in pipes due to leakage. Water leaks in water distribution networks (WDN) are unavoidable. They can cause significant economic losses in fluid transportation and an increase on reparation costs that finally generate an extra cost for the final consumer due to the waste of energy and chemicals in water treatment plants. It may also damage infrastructure and cause third party damage and health risks. In many WDN, losses due to leakage are estimated to account up to 30% of the total amount of extracted water; a very important issue in a world struggling to satisfy water demands of a growing population.Telemetry systems have long been used in large water distribution systems for improving real-time monitoring of quantity and quality parameters. As monitoring technologies 2 evolve, new possibilities of controlling and managing complex infrastructures are provided. This is the case for water networks. Sectorization of distribution networks into smaller subnetworks, such as District Metered Areas (DMAs), contributes to achieving, in real-time, an accurate estimation of the amount of water that is being consumed in each subnetwork. It is an efficient measure to control water loss, since flow and pressure meters bring a huge amount of data with information about the network behavior. Over the last decade, the concepts and methods developed for system-wide water balance calculations have been based upon water assets' physical data and the statistics of pipe bursts, service connections and underground conditions [1]. Performance measures and indicators are used to support the managerial approaches to minimize different components of water losses.Real-time monitoring of water networks is based on the use of sensor data from telemetry and mathematical models to detect and diagnose possible abnormal situations, such as leakage or water quality deterioration events. It links the real sensor data gathered from the network to the decision making procedure, by detecting possible faults as well as their probable location within the network. The main idea behind real-time monitoring, both for water balance and for water quality problems, is to use real-time sensor data and to compare them with those generated by a well-calibrated hydraulic model of the network in absence of faults. By analyzing the difference between these two sets of data, a detection of abnormal events can be performed.Several works have been published on leak detection and isolation methods for WDN.For example, a review of transient-based leak detection methods is offered in [2] as a summary of current and past work. In [3], a method has been proposed to identify leaks using blind spots based on previously leak detection researches that use the analysis of acoustic and vibrations signals [4], and models of buried pipelines to predict wave velocities [5]. ...