Methods for collecting individual components of mixed saliva: the relevance to clinical pharmacology.

Abstract

Methods are described for collecting constituents of mixed saliva, viz. parotid, submandibular, monor gland and sublingual saliva and gingival fluid. Literature is cited which showed that using these techniques, few antibiotics could be found in mixed saliva or its main components but all were detected in gingival fluid. Rifamicin and clindamycin were found in all components.

Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring

“…Similar findings have been reported by others (Kostlin & Rauch, 1957;Mason & Chisholm, 1975 & Speirs, 1976;Speirs, 1977). The various secretions show some differences in composition, and differences between gingival fluid and the glandular secretions are particularly marked (Mason & Chisholm, 1975).…”

“…In contrast to our experience with (Stephen & Speirs, 1976). An important disadvantage of saliva sampling is that it is unsuitable for oral medications other than capsule formulations, because only the latter prevent direct contamination of saliva by the drug (Speirs et al, 1971;Graham & Rowland, 1972).…”

“…To avoid this problem, Stephen & Speirs (1976) recommended the collection of individual components of mixed saliva, for which techniques are available (Mason & Chisholm, 1975;Stephen & Speirs, 1976). However, in using these methods much of the simplicity of mixed-saliva sampling would be lost.…”

Oral absorption and secretion of drugs.

“…Saliva (mixed saliva or spit) consists of parotid, submandibular, sublingual and minor gland secretions along with gingival fluid. Mason & Chisholm (1975) There are methods for collecting the components of mixed saliva (Stephen & Speirs, 1976) but most published studies of salivary drug concentrations relate only to mixed saliva. Low concentrations of sulphapyridine (M & B 693) were detected in the saliva of patients who had received oral or intramuscular therapy (Fickling, Pincus & Boyd-Cooper, 1939).…”

Reproducibility of saliva and plasma theophylline levels following single dose administration of two sustained release preparations.

“…(Stephen & Speirs, 1976). Individual variation in elimination rates of theophylline is well recognised (Ogilvie, 1978) and variability in the plasma profiles of theophylline following repeated single dose administration has been noted by Dederich et al (1981) (Mucklow, 1982).…”