In order to increase the economic efficiency of oilseeds production in the soil and climatic conditions of the Republic of Tatarstan in 2020-2022 a comparative assessment of the chemical and biological system of sunflower protection from basket rot was carried out. The scheme of the experiment included the following options: background nutrition (factor A) - without fertilizers (control), N104P50K106 (for a planned yield of 2.5 t/ha), partial replacement of mineral fertilizers with a biopreparation Biostim oil (N52P25K53 + foliar top dressing Biostim oil 3 l/ha in the budding phase); protection system (factor B) - seed treatment with chemicals Imidor Pro, KS, 15 l/t + Scarlet, ME, 0.4 l/t (control); treatment of seeds with biological preparations (Nodix Insectobact, 2 l/t + Nodix Biofungicide, 0.5 l/t); spraying crops in the phase of sunflower budding with chemical plant protection products (Mystery, ME, 2 l/ha + Karate Zeon, 0.15 l/ha); spraying crops with biological preparations (Nodix Insectobact, 2 l/ha + Nodix Biofungicide, 0.5 l/ha). The biological system for protecting sunflower from basket rot and replacing part of the mineral fertilizers with the biopreparation Biostim oil had high efficiency: treatment of crops with Nodix Biofungicide, 0.5 l/ha in combination with Nodix Insectobact, 2 l/ha against the background of N52P25K53 + Biostim oil, 3 l/ha ha, on average, ensured the collection of 2.31 t/ha of sunflower oilseeds. Spraying of crops with biological preparations from basket rot in combination with foliar top dressing with a fertilizer-stimulating composition Biostim oilseed made it possible to obtain 22.5 thousand rubles/ha of net profit, the profitability was 53.6%, the cost of production of 1 ton of oilseeds was 18.3 thousand rubles. rub. at a selling price of grown products of 28 thousand rubles.