Methods for preparation of nanostructured lipid carriers

Gomaa, Eman Zakaria; Fathi, Heba A.; Eissa, Noura G.; Elsabahy, Mahmoud

doi:10.1016/j.ymeth.2021.05.003

Cited by 48 publications

(12 citation statements)

References 34 publications

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“…The NLC and SLN, the subtypes of the lipid-based nanoparticles, were fabricated using hot high-energy homogenization techniques [ 21 ]. As shown in Table 1 , the oil phase was prepared using 17 alpha-methyltestosterone as a solid lipid (200 mg) and MCT as a liquid lipid (5 g only for the fabrication of NLC).…”

Section: Methodsmentioning

confidence: 99%

Masculinization of Red Tilapia (Oreochromis spp.) Using 17α-Methyltestosterone-Loaded Alkyl Polyglucosides Integrated into Nanostructured Lipid Carriers

Yostawonkul

Kitiyodom

Supchukun

et al. 2023

Animals

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The aim of the present study was to optimize a masculinization platform for the production of all-male red tilapia fry by oral administration of 30 and 60 ppm of MT and alkyl polyglucoside nanostructured lipid carriers (APG-NLC) loaded with MT, respectively, for 14 and 21 days. The characterization, encapsulation efficiency and release kinetics of MT in lipid-based nanoparticles were assessed in vitro. The results showed that the MT-loaded nanoparticles were spherical, ranging from 80 to 125 nm in size, and had a negative charge with a narrow particle distribution. The APG-NLC loaded with MT provided higher physical stability and encapsulation efficacy than the NLC. The release rate constants of MT from MT-NLC and MT-APG-NLC were higher than those of free MT, which is insoluble in aqueous media. There was no significant difference in survival between the fish administered MT or the those fed orally with MT-APG-NLC fish. According to the logistic regression analysis, the sex reversal efficacy of MT-APG-NLC (30 ppm) and MT (60 ppm), resulted in significantly higher numbers of males after 21 days of treatment compared with the controls. The production cost of MT-APG-NLC (30 ppm) after 21 days of treatment was reduced by 32.9% compared with the conventional MT treatment group (60 ppm). In all the treatments, the length–weight relationship (LWR) showed negatively allomeric growth behavior (b < 3), with a relative condition factor (Kn) of more than 1. Therefore, MT-APG-NLC (30 ppm) would seem to be a promising, cost-effective way to reduce the dose of MT used for the masculinization of farmed red tilapia.

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Section: Methodsmentioning

confidence: 99%

Masculinization of Red Tilapia (Oreochromis spp.) Using 17α-Methyltestosterone-Loaded Alkyl Polyglucosides Integrated into Nanostructured Lipid Carriers

Yostawonkul

Kitiyodom

Supchukun

et al. 2023

Animals

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“…67,68 High-pressure homogenization, 69 melt-emulsification, 70 emulsification-solvent evaporation (Fig. 4D), 71,72 ultra-sonication, 73 solvent-diffusion, 73 and spray drying techniques 74 are used in the fabrication of NLCs. The normal weight ratio of solid lipid to liquid lipid ranges from 70 : 30 to 90 : 10.…”

Section: Fabrication Of Functional Transdermal Nano-systemsmentioning

confidence: 99%

Functional nano-systems for transdermal drug delivery and skin therapy

Liu

Zhao

et al. 2023

Nanoscale Adv.

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“…The methods that are typically employed for the production of NLCs include film-ultrasonic, evaporation-low temperature solidification, high-pressure homogenization, microemulsion, supercritical fluid, membrane contactor, solvent dispersion, microchannel, and microtubes [ 145 ].…”

Section: Outline Of Nanotechnological Aspects Explored For Daidzein I...mentioning

confidence: 99%

Unveiling the Pharmacological and Nanotechnological Facets of Daidzein: Present State-of-the-Art and Future Perspectives

et al. 2023

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Herbal drugs have been attracting much scientific interest in the last few decades and nowadays, phytoconstituents-based research is in progress to disclose their unidentified medicinal potential. Daidzein (DAI) is the natural phytoestrogen isoflavone derived primarily from leguminous plants, such as the soybean and mung bean, and its IUPAC name is 4′,7-dihydroxyisoflavone. This compound has received great attention as a fascinating pharmacophore with remarkable potential for the therapeutic management of several diseases. Certain pharmacokinetic properties of DAI such as less aqueous solubility, low permeability, and poor bioavailability are major obstacles restricting the therapeutic applications. In this review, distinctive physicochemical characteristics and pharmacokinetics of DAI has been elucidated. The pharmacological applications in treatment of several disorders like oxidative stress, cancer, obesity, cardiovascular, neuroprotective, diabetes, ovariectomy, anxiety, and inflammation with their mechanism of action are explained. Furthermore, this review article comprehensively focuses to provide up-to-date information about nanotechnology-based formulations which have been investigated for DAI in preceding years which includes polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carrier, polymer-lipid nanoparticles, nanocomplexes, polymeric micelles, nanoemulsion, nanosuspension, liposomes, and self-microemulsifying drug delivery systems.

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Methods for preparation of nanostructured lipid carriers

Cited by 48 publications

References 34 publications

Masculinization of Red Tilapia (Oreochromis spp.) Using 17α-Methyltestosterone-Loaded Alkyl Polyglucosides Integrated into Nanostructured Lipid Carriers

Masculinization of Red Tilapia (Oreochromis spp.) Using 17α-Methyltestosterone-Loaded Alkyl Polyglucosides Integrated into Nanostructured Lipid Carriers

Functional nano-systems for transdermal drug delivery and skin therapy

Unveiling the Pharmacological and Nanotechnological Facets of Daidzein: Present State-of-the-Art and Future Perspectives

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