Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use

Abstract

Following previously published systematic reviews on the diagnostic use of nanoparticles (NPs), in this manuscript, we report published methods for radiolabeling nanoparticles with therapeutic alpha-emitting, beta-emitting, or Auger’s electron-emitting isotopes. After analyzing 234 papers, we found that different methods were used with the same isotope and the same type of nanoparticle. The most common type of nanoparticles used are the PLGA and PAMAM nanoparticles, and the most commonly used therapeutic isotope is 177Lu. Regarding labeling methods, the direct encapsulation of the isotope resulted in the most reliable and reproducible technique. Radiolabeled nanoparticles show promising results in metastatic breast and lung cancer, although this field of research needs more clinical studies, mainly on the comparison of nanoparticles with chemotherapy.

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

“…Because of some intrinsic properties such as non-immunogenicity, nontoxicity, biocompatibility, and biodegradability, polymeric NPs are used in nanostructures as an alternative approach [140]. The biodegradable polymer poly(lactic-co-glycolic) acid has been shown to have significant potential as a drug delivery vehicle [141][142][143][144][145].…”