Methods for the synthesis of thyroxine and triiodothyronine

Кочергин, П. М.; Palei, R. M.; Кравченко, Ангелина Н.; Попова, Е. В.

doi:10.1007/bf00765794

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2006

2014

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“…al [21]. The recent paper generalizes the results achieved in the chemical model-ing of TH biosynthesis, most of which have been published in the last twelve years.…”

mentioning

confidence: 53%

Obtaining thyroid hormones by chemical methods based on biosynthesis modeling (a review)

Martinovich

Sviridov

2006

Pharm Chem J

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This review considers the methods of synthesis of thyroxine and triiodothyronine, which were developed on the basis of hypothetical models of their biosynthesis in the organism. Most of such methods are based on the use of highly active derivatives of phenols or quinones (4-hydroxy-3,5-diiodophenylpyruvic acid, iodine-containing derivatives of spiro-4-epoxycyclohexadienone, 2,4,6-tri-tert-butylphenol, etc.) as arylating agents. Condensation of these compounds with 3,5-derivatives of tyrosine results in the formation of substituted diaryl esters, representing thyroid hormones or their analogs. Some of the proposed methods are highly effective and lead to high yields of thyroid hormones, which can be used as parent drug substances.

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“…al [21]. The recent paper generalizes the results achieved in the chemical model-ing of TH biosynthesis, most of which have been published in the last twelve years.…”

mentioning

confidence: 53%

Obtaining thyroid hormones by chemical methods based on biosynthesis modeling (a review)

Martinovich

Sviridov

2006

Pharm Chem J

View full text Add to dashboard Cite

show abstract

“…Levothyroxine is produced by multistep chemical synthesis [4,5]. It is distributed by the manufacturer in the crystalline form of a sodium pentahydrate, which has been reported to be stable for more than 4 years at defined conditions of 25 • C and 60% humidity [6].…”

Section: Introductionmentioning

confidence: 99%