Methods for volume assessment of prostate cancer

Schlemmer, Heinz Peter; Corvin, Stefan

doi:10.1007/s00330-004-2233-4

Cited by 14 publications

(13 citation statements)

References 74 publications

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“…It was also demonstrated that also contrast enhanced dynamic MRI can improve the detection of prostate cancer [8][9][10]. Detailed assessment of tumour localization and extent is also important for planning minimally invasive therapeutic strategies [25][26][27].…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5�T in clinical routine: a feasibility study

et al. 2004

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The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils.

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Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5�T in clinical routine: a feasibility study

et al. 2004

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“…However, an imaging method clearly discriminating cancer from normal prostate tissues could increase the accuracy of biopsy, improve the selection and follow-up of patients under watchful waiting, allow a better focusing of new disease-targeted ablative therapies (such as brachytherapy, high-intensity focused ultrasound, or cryosurgery), and, probably, a better local staging of the tumor [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prostate dynamic contrast-enhanced MRI with simple visual diagnostic criteria: is it reasonable?

et al. 2006

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“…It is commonly known that prostate cancers affect the prostatic contour 4–6 . McNeal and Haillot investigated 571 radical prostatectomy specimens, and demonstrated patterns of cancer volume, cancer spread direction and contour alterations 6 .…”

Section: Discussionmentioning

confidence: 99%

“…TRUS is now recognized as a tool to lead a biopsy needle to the appropriate prostatic portions, not as a diagnostic tool for a confined lesion in the prostate 2 . MRI, with powerful spatial resolution, is considered to give the highest accuracy in the preoperative staging in prostate cancer, 2 and has been substantially improved, but it was not sufficient for reliable prediction for clinical decision making 4 . In contrast, altered prostatic contours, some of which are caused secondarily by prostate cancer, are also important findings.…”

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confidence: 99%

“…In contrast, altered prostatic contours, some of which are caused secondarily by prostate cancer, are also important findings. It has been suggested that distortion of gland shape or contour alterations can represent secondary indications of prostate cancer 4–6 . However, to the best of knowledge, few reports have systematically investigated the association between distortion of gland shape or contour alterations and prostate cancer 5,6 .…”

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Histopathological approach to prostatic contour alterations with the concept of left–right asymmetry

Kiyoshima¹,

Oda²,

Tamiya³

et al. 2006

Pathology International

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It has been suggested that prostate cancer spread has predictable patterns, with prostate cancers known to affect the prostatic contours. However, few systematic investigations have documented the associated contour alterations, especially at a clinically localized stage. The purpose of the present paper was to objectively evaluate prostatic contour alterations based on left-right asymmetry, and analyze the histopathological features and prognostic impact. One hundred and sixty-two asymmetrical contours with left-right asymmetry in the length >or=10%, and 278 cancer foci were observed in 114 radical prostatectomy specimens. Of the asymmetrical contours, 55 (34%) were caused by cancer, and of the cancer foci, 55 (20%) generated asymmetrical contours. Cancer-associated asymmetries showed significant correlations with aggressive behaviors such as cancer volume, Gleason score, positive surgical margin, and extraprostatic extension, although these were not significantly associated with unfavorable prognosis. The authors present basic data relating to altered prostatic contours, such as spatial distribution and causative pathological conditions. Clinicopathological characteristics concerning cancer-associated contour alterations, are also presented in detail.

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Methods for volume assessment of prostate cancer

Abstract: This paper presents current knowledge on the prognostic significance of prostate cancer volume, reviews the feasibility of state-of-the-art imaging techniques for its assessment, and briefly introduces future perspectives regarding technical developments.

Cited by 14 publications

References 74 publications

3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5�T in clinical routine: a feasibility study

3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5�T in clinical routine: a feasibility study

Prostate dynamic contrast-enhanced MRI with simple visual diagnostic criteria: is it reasonable?

Histopathological approach to prostatic contour alterations with the concept of left–right asymmetry

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