Methods in Determination of Formaldehyde

Formaldehyde produced from d-ribose under neutral and alkaline conditions

“…However, increases of liver formaldehyde levels could not be significantly observed though it has hepatotoxicity, similar to other toxicants such as carbon tetrachloride [53] and imazamox [54]. In spite of these data from mice, they reminds us that humans should have their serum and urine formaldehyde measured when they receive d -ribose as a supplement [55], especially a high dosage of pentose for a long period.…”

Simple and fast microderivatization method for determining formaldehyde using narrow-bore liquid chromatography with UV detection

“…In formaldehyde analysis, the most commonly used derivatizing agent is 2,4-dinitrophenylhydrazine (2,4-DNPH), which reacts readily with carbonyls to produce 2,4dinitrophenylhydrazones. [32][33][34] The various methods used in formaldehyde analysis from 1961 to 2017 were summarized by Su et al 34 Backe 35 summarized the many disadvantages of using 2,4-DNPH as the reagent, including the risk of shock-sensitive explosion of 2,4-DNPH, requirement for concentrated acidic conditions for the reaction, and instability of the derivative at low pH values. In this study, 3-aminoquinoline (3-AQ) was the rst used as the microderivatization reagent and reacted with formaldehyde under mild conditions without the use of a catalyst or activator.…”