Background-The creep-fatigue properties of stainless steel 316 are of interest because of the wide use of this material in demanding service environments, such as the nuclear industry. Need-A number of models exist to describe creep-fatigue behaviours, but they are limited by the need to obtain specialized coefficients from a large number of experiments, which are time-consuming and expensive. Also, they do not generalise to other situations of temperature and frequency. There is a need for improved formulations for creep-fatigue, with coefficients that determinable directly from the existing and simple creep-fatigue tests and creep rupture tests. Outcomes-A unified creep-fatigue equation is proposed, based on an extension of the Coffin-Manson equation, to introduce dependencies on temperature and frequency. The equation may be formulated for strain as ε p = C 0 c T, t, ε p N −β 0 , or as a power-law ε p = C 0 c (T, t) N −β 0 b(T,t) . These were then validated against existing experimental data. The equations provide an excellent fit to data (r 2 = 0.97 or better). Originality-This work develops a novel formulation for creep-fatigue that accommodates temperature and frequency. The coefficients can be obtained with minimum experimental effort, being based on standard rather than specialized tests.