Methods of determining immunity, duration and character of immunity resulting from measles

Enders-Ruckle, G

doi:10.1007/bf01253808

Cited by 42 publications

(12 citation statements)

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“…Other possible determinants of measles antibody level include age, sex and race, which are considered important variables in epidemiologic studies. Residual measles antibody does decline gradually with increasing age (and remoteness of primary infection (8), but our study suggests this may in part reflect the gradual decline of IgG from the third to the seventh decades shown by others (9). Since IgG levels also vary according to sex and race (9), IgG may be a common factor in the importance of these variables as well.…”

contrasting

confidence: 44%

The Influence of Serum Immunoglobulin Concentration on Measles Antibody Level

Phillips¹,

Christian²

1972

Experimental Biology and Medicine

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contrasting

confidence: 44%

The Influence of Serum Immunoglobulin Concentration on Measles Antibody Level

Phillips¹,

Christian²

1972

Experimental Biology and Medicine

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“…The Edmonston strain of measles virus was grown in LLC-MK2 cells. The haemagglutimin was titrated at 370C in WHO trays, one unit calculated, and four units used in the test (Enders-Ruckle, 1965). Due to the relatively large volumes required, not all specimens could be tested by the haemagglutination inhibition (HI) test.…”

Section: Methodsmentioning

confidence: 99%

Application of immunofluorescence to a study of measles.

McQuillin¹,

Bell²,

Gardner³

et al. 1976

Archives of Disease in Childhood

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to a study of measles. A new and rapid method for the laboratory diagnosis of measles, using the fluorescent antibody technique applied to nasopharyngeal secretions is described. The reliability of the method was best shown by correlation with clinical diagnosis, which gave an overall agreement of 95°00 in 53 cases of typical clinical measles and 72 control children. Correlation with results of tissue culture and serology was also good, though these methods are in practice too infrequently successful to be used as the main standards of reliability. The antiserum used for immunoflorescence showed no cross-reactivity with other viruses. Viruses could be identified by the fluorescent antibody technique from 4 days before to 10 days after the onset of the rash in a high proportion of cases.The wider applications of this method include rapid diagnosis of measles before the rash has appeared; in cases where clinical diagnosis is in doubt, especially in darkskinned children, or when the illness has been modified by previous vaccination; prevention of cross-infection by early detection of measles; and investigation of the immune reponse and its relationship to nutritional status.

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“…Table 2 shows the association between a history of artificial and natural immunity to measles and presence of measles antibody in serum. Children with a The hemagglutination-inhibitio!n test is more sensitive (8,9) and may have accounted for finding a greater number of immune children who would have been missed with less sensitive antibody tests. Finally, the difference in agespecific immunity may reflect early measlels exposure of poverty area Pittsburgh children as compared with children in Black's study.…”

Section: Use Of a Questionnaire To Estimatementioning

confidence: 98%