Methods Of Spectrophotometric Determination Of Sulphanilamides. Review

Determination of trace amount of some drugs as in its pure form and in its Pharmaceutical Preparations by using different spectroscopic methods

“…The organic and pharmaceutical compounds have been estimated using traditional methods such as gravimetric (48,49) and volume (50,51,52,53) of different types, but these methods did not respond to the possibility of determination trace quantities of these compounds, as well as chemical interference and length of analysis time, and this is what led there is an increasing need to estimate trace or archaeological quantities of such compounds in various samples of industrial, food and biological sources such as blood, urine, etc., using automatic and high-sensitivity methods. The most prominent of these is the direct and indirect determination using flame and thermo atomic absorption spectroscopy because of the advanced advantages of this technique, including:…”

A New Approach for the Voltammetric Determination of Amoxicillin in the Dosage Form Using Azo Coupling Reaction with Sulphanilamide

“…According to the literature review, an azo coupling reaction between sulphanilamides diazonium salt and phenolic compounds occurs in an alkaline medium at pH 9-11 [31,32,35,36]. To develop a voltammetric technique, the optimal value of the acidity of the medium to obtain the maximum analytical signal was investigated.…”

“…SA has amphoteric properties, in particular exhibits basic properties due to the presence of aromatic amino group. Acidic properties are more pronounced due to the presence of sulphamidic group in the molecule, which contains a mobile hydrogen atom (Scheme 2) [31]:…”

“…SA as an analytical reagent has not been used before in the chemical analysis [31]. We were first to apply sulphanilamide for the spectrophotometric determination of AM [32].…”