Methotrexate for refractory prurigo nodularis

Zaabi, Mariam Al Al; Suwaiji, Mohammad Al Al; Nasir, Manal

doi:10.7241/ourd.20171.10

Cited by 2 publications

(5 citation statements)

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“…In recent studies, numerous counts and different morphologies of mast cells in prurigo nodularis lesions were documented. Nerve growth factor was produced abundantly by mast cells in prurigo nodularis lesions [3]. In histopathology, focal parakeratosis, hypergranulosis and acanthosis of the epidermis, dense dermal infiltrate consisting of neutrophils, eosinophils, histiocytes and monocytes can be observed.…”

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confidence: 99%

“…Treatment options for prurigo nodularis are limited by studies. Most of the studies aim at symptomatic relief of patients [3].A 49-year-old female patient applied to our clinic with an 8-year history of itchy nodular lesions on the back and extensor surfaces of extremities. She has had recurrent upper respiratory tract infections and natural killer deficiency in her history.…”

mentioning

confidence: 99%

“…Treatment options for prurigo nodularis are limited by studies. Most of the studies aim at symptomatic relief of patients [3].…”

mentioning

confidence: 99%

“…Na podstawie dostępnych badań możliwości leczenia świerzbiączki guzkowej są ograniczone. W większości prac autorzy podają, że leczenie ukierunkowane jest na łagodzenie objawów [3].…”

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“…W ostatnio przeprowadzonych badaniach w zmianach typowych dla świerzbiączki guzkowej obserwowano dużą liczbę mastocytów o zróżnicowanej morfologii. W zmianach w przebiegu świerzbiączki guzkowej stwierdzono wzmożone wytwarzanie czynnika wzrostu nerwów przez komórki tuczne [3]. W obrazie histopatologicznym widoczne są ogniska hiperkeratozy, hipergranuloza i akantoza naskórka oraz gęsty naciek skórny złożony z neutrofilów, eozynofilów, histiocytów i monocytów.…”

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Prurigo nodularis responding to intravenous immunoglobulins

Durmaz¹,

Ataseven²,

Özer³

et al. 2022

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Prurigo nodularis is a chronic skin disease, especially seen in middle-aged women adults. It is characterized by symmetric, pruritic hyperkeratotic nodules and papules on the extensor surfaces [1]. Prurigo nodularis patients can suffer from repeated itching and scratching cycles or intensive pruritus. The etiology of prurigo nodularis is not clear. The lesions can be seen primarily or be caused by another pruritic condition. The trigger can be other dermatoses such as atopic dermatitis or secondary pruritus due to another systemic disease such as chronic kidney disease, jaundice, malignancies, etc. The interaction between cutaneous nerve fibers and immune cells can play a crucial role in pathogenesis [2]. Treatment options for prurigo nodularis are limited by studies. Most of the studies aim at symptomatic relief of patients [3].A 49-year-old female patient applied to our clinic with an 8-year history of itchy nodular lesions on the back and extensor surfaces of extremities. She has had recurrent upper respiratory tract infections and natural killer deficiency in her history. She had taken many topical and systemic agents for prurigo nodularis be-Letter to the editor/List do redakcji prurigo nodularis responding to intravenous immunoglobulins Świerzbiączka guzkowa leczona dożylnie immunoglobulinami koray durmaz 1 , arzu ataseven 2 , ilkay ozer 2 , sıddıka Fındık 3

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confidence: 99%

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confidence: 99%

“…Treatment options for prurigo nodularis are limited by studies. Most of the studies aim at symptomatic relief of patients [3].…”

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confidence: 99%

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