Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway

Kim, Joo-Young; Yi, Bo‐Rim; Go, Ryeo‐Eun; Hwang, Kyung‐A; Nam, Ki-Hoan; Choi, Kyung‐Chul

doi:10.1016/j.etap.2014.04.013

Cited by 67 publications

(42 citation statements)

References 35 publications

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“…Se ha investigado la citoxicidad del TCS en células empleadas como modelos para explorar la relación del compuesto con lesiones endócrinas, pues se sugiere que el TCS es un químico perturbador del sistema endócrino y consecuentemente cancerígeno (11). En la línea celular MCF-7 BOS, el TCS tuvo una actividad estrogénica y anti-estrogénica y en una línea celular derivada de cáncer de ovario, el TCS incrementó significativamente la proliferación de las células (11,22).…”

Section: Endócrino-toxicidad Y Cáncerunclassified

“…En la línea celular MCF-7 BOS, el TCS tuvo una actividad estrogénica y anti-estrogénica y en una línea celular derivada de cáncer de ovario, el TCS incrementó significativamente la proliferación de las células (11,22). También ha disparado la proliferación de células de cáncer de mama MCF-7 y cuando las células fueron trasplantadas a ratones, el efecto del TCS aceleró el crecimiento y densidad de tumores (24).…”

Section: Endócrino-toxicidad Y Cáncerunclassified

“…Sin embargo, en años recientes las PTCS han estado en boca de todos -clínica y metafóricamente hablandoporque diversas investigaciones han mostrado que el TCS provoca cáncer en modelos animales, entonces podría también ser un factor de riesgo de cáncer en humanos (11)(12)(13). Las observaciones no han pasado desapercibidas ante la opinión pública e importantes medios electrónicos han hecho reportajes sobre el riesgo del uso de TCS, incluso como resultado de la presión social, algunos fabricantes de productos de belleza han retirado el TCS de sus productos, eso al mismo tiempo que otros han rechazado que el TCS cause daños a la salud (14)(15)(16)(17).…”

Section: Introductionunclassified

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Triclosan in Toothpaste, Is There Any Real Risk for the Health?

García

Sánchez

Galindo

et al. 2016

Odovtos - Int J Dent Sc

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Triclosan is an antimicrobial drug that is widely used in products for human hygiene, beauty and home cleanliness. It is a common compound in toothpaste that have showed efficacy on the control and treatment of gingivitis. However, during the last decade, the triclosan has been extensively investigated because of its cytotoxicity, its ability to disturb cellular mechanisms on endocrine-system cells, and because of its cancerogenic in vitro and in vivo properties. Moreover, public opinion has paid attention to the toxic action of the triclosan. Thus, the dentist should know the state of the art about the detrimental effects of triclosan on patients’ health. This review explores the triclosan on its cytotoxicity, in vitro and in vivo cancerogenic effects, absorption in humans, and the toxic effects caused by triclosan toothpaste.

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Section: Endócrino-toxicidad Y Cáncerunclassified

Section: Introductionunclassified

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Triclosan in Toothpaste, Is There Any Real Risk for the Health?

García

Sánchez

Galindo

et al. 2016

Odovtos - Int J Dent Sc

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“…Recent studies have focused that endocrine-disrupting chemicals (EDCs) may act as an exogenous factor to enhance cancer progression (Kim et al, 2014;Park et al, 2013). EDCs are chemical substances that interfere with the endocrine functions in animals and humans and they are commonly encountered in our environment from daily consumptions of foods and consumer products.…”

Section: Introductionmentioning

confidence: 99%

Growth and migration of LNCaP prostate cancer cells are promoted by triclosan and benzophenone-1 via an androgen receptor signaling pathway

Kim

Hwang

Shim

et al. 2015

Environmental Toxicology and Pharmacology

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“…In addition, triclosan is used as a common component of soaps, deodorants, toothpastes, and other hygiene products at concentrations up to 0.3%. Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle and apoptosis-related genes via an estrogen receptor-dependent pathway [110]. The methoxychlor metabolite, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE).…”

Section: Ovarian Cancermentioning

confidence: 99%

Adverse Effects on Female Human Reproductive Health from Exposure to Endocrine Disruptors: Focus on Endometrial Lesions

Karoutsou¹,

Karoutsos²,

Karoutsos³

2016

J Clin Epigenet

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It is currently apparent that the intentional release of compounds through agricultural, industrial, and municipal activities has influenced the health of wildlife and human populations. Scientists are invited to study disturbances in the normal function of the reproductive system of genetically modified populations. When referring to a population, they rather use the term control or reference; the reason is an enormous rate of information concerning the endocrine-altering potential of plasticizers and dyes, as well as the possible influences of pesticides and industrial compounds on various endocrine endpoints, particularly regarding the concentration of estrogens. Here in, we provide an overview on the impact of chemical substances on female human reproductive health.

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Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle- and apoptosis-related genes via an estrogen receptor-dependent pathway

Cited by 67 publications

References 35 publications

Triclosan in Toothpaste, Is There Any Real Risk for the Health?

Triclosan in Toothpaste, Is There Any Real Risk for the Health?

Growth and migration of LNCaP prostate cancer cells are promoted by triclosan and benzophenone-1 via an androgen receptor signaling pathway

Adverse Effects on Female Human Reproductive Health from Exposure to Endocrine Disruptors: Focus on Endometrial Lesions

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