Methyl (1-benzamido-2-methoxy-2-oxoethyl)tryptophanate

Abstract

The title molecule, C 22 H 23 N 3 O 2 , is U-shaped, with a dihedral angle of 80.76 (9) between the indole ring system and the phenyl ring. In the crystal, N-HÁ Á ÁO hydrogen bonds combine with N-HÁ Á Á and C-HÁ Á Á interactions to generate a three-dimensional structure. Structure descriptionThe molecule of the title compound is approximately U-shaped, Fig. 1, with the indole ring system and the benzene ring linked by a complex alaninate chain and with a dihedral angle of 80.76 (9) between them. This conformation is supported by an intramolecular C5-H5Á Á ÁCg3 interaction (Table 1).In the crystal, classical N3-H3NÁ Á ÁO1 hydrogen bonds together with unusual intermolecular N2-H2NÁ Á ÁCg2 contacts and C20-H20Á Á ÁCg1 interactions combine to generate a three dimensional network, Fig. 2. Synthesis and crystallizationTo a solution of 2.6 mmol of N-protected methyl -azidoglycinate and 3.12 mmol of diisopropylethylamine (DIEA) in 10 ml of acetone, 2.86 mmol of 2-amino-3-(1H-indol-3-yl)propanoate was added. The reaction mixture was stirred at room temperature. The solvent was evaporated under reduced pressure. The residue was quenched with saturated aqueous solution of ammonium chloride (20 ml) and extracted with methylene chloride (3 Â 20 ml). The organic layer was dried over sodium sulfate (Na 2 SO 4 ) and the

Comparative Study of Synthesis, Structural and Antioxidant Activity In Vitro of Some New Carboxylic α,α-diaminodiesters Derivatives

“…Fig.2. ORTEP view of compound 2b showing the atomic numbering scheme.The methyl 2-((1-benzamido-2-methoxy-2oxoethyl)amino)-3-(3a,7a-dihydro-1H-indol-3yl)propanoate derivative 2c, with the empirical formula C22H23N3O2, crystallizes in the Orthorhombic system with space group P212121[41].…”