Methyl (3aRS,3cRS,6cSR,7RS,8RS,8aSR)-2,5-bis(4-chlorophenyl)-7,9-bis(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4,6-tetraoxododecahydro-1H-dipyrrolo[3,4-a:3′,4′-f]pyrrolizine-3b-carboxylate dimethylformamide disolvate: a three-dimensional hydrogen-bonded framework

Abstract

The racemic title dipyrrolopyrrolizine compound crystallizes from dimethylformamide as a disolvate, C(55)H(39)Cl(2)N(7)O(6)·2C(3)H(7)NO. None of the four fused heterocyclic rings is planar; one adopts an envelope conformation, two others adopt half-chair conformations and the fourth adopts a conformation intermediate between an envelope and a half-chair. The arrangement of the ring fusions is such as to preclude the possibility of internal mirror symmetry. The three independent molecular components are weakly linked by C-H···O hydrogen bonds, and the dipyrrolopyrrolizine molecules are linked by a combination of four C-H···O and one C-H···π(arene) hydrogen bond to form a three-dimensional framework, from which the dimethylformamide solvent molecules are pendent. However, aromatic π-π stacking interactions are absent in the structure.

Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

“…Two of them appear as triplets corresponding to the H-6a and H-9a protons, and the remaining four appear as doublets assigned to the H-3a, H-3c, H-7 and H-9 protons. Crystals of compound 4g suitable for single-crystal X-ray diffraction were obtained by slow evaporation from a DMF:EtOH (1:1), thus solution confirming the structure and stereochemistry of the racemic compounds 4a – j (Figure 2) [38].…”