Methyl 5-methylpyrazine-2-carboxylate

Abstract

In the structure of methyl 5-methyl-2-pyrazinecarboxylate, C7H8N2O2, the non-H atoms of the molecule are nearly planar, with a dihedral angle of 5.4 (1)° between the plane of the pyrazine ring and the plane defined by C—C(O)—O. In the crystal, molecules are linked via C—H...N and C—H...O hydrogen bonds, forming layers parallel to (100).

5-Methylpyrazine-2-carboxamide

“…1. The bond lengths of the methylpyrazine component are similar to those found in methyl 5-methyl-2-pyrazinecarboxylate (Rillema et al, 2017). The molecule is planar with a dihedral angle of 2.14 (11) between the pyrazine ring (N2/N3/C2-C5) and the mean plane of the carboxamide group [atoms C2-C1( O1)-N1].…”

“…Methyl 5-methyl-2-pyrazinecarboxylate (80.0 g, 0.657 mole) (Rillema et al, 2017) was added to 600 ml of methanol in a 1 litre round-bottomed flask. The flask was immersed in an ice bath, the contents were cooled to ca 273 K, stirred with a magnetic stirrer and then purged with ammonia gas for 4 h. The reaction progress was monitored by thin-layer chromatography (TLC).…”

Synthesis and Characterization of 2‐(2‐Pyridinyl)pyrazine and 2,2′‐Bipyrazine Derivatives

“…Among these, compounds 11 and 12 are reported in this present work. Compounds 9 and 10 were previously reported by our group .…”