“…The data on Mat2a prompted us to probe our dataset for other genes involved in 1-carbon metabolism, which we have previously shown is enriched with rhythmically expressed genes in the liver 17 . Out of a list of 49 genes coding for enzymes and transporters involved in 1C metabolism, 27 genes had a BICW>0.8: 7 were classified as non-rhythmic in both conditions (Aldh1l2, Mtap, Ftcd, Sms, Mthfsd, Slc25a26, Mthfd1), 1 lost rhythm in MCD-fed liver (Srm), 4 gained rhythms in MCD-fed liver (Mat2b – the regulatory beta subunit of methionine adenosyltransferase 31,32 , Cth, Chdh, Tyms), 13 had identical rhythms in both condition (Slc19a1, Mtrr, Bhmt2, Slc25a32, Dhfr, Mthfd1l, Bhmt, Ahcy, Fpgs, Amd2, Gart, Tat, Atic) and 2 had changed rhythms (Mat2a, Cbs) (Supplemental Data 2).…”