2022
DOI: 10.1177/07487304221083507
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Methyl Metabolism and the Clock: An Ancient Story With New Perspectives

Abstract: Methylation, that is, the transfer or synthesis of a –CH3 group onto a target molecule, is a pervasive biochemical modification found in organisms from bacteria to humans. In mammals, a complex metabolic pathway powered by the essential nutrients vitamin B9 and B12, methionine and choline, synthesizes S-adenosylmethionine, the methyl donor in the methylation of nucleic acids, proteins, fatty acids, and small molecules by over 200 substrate-specific methyltransferases described so far in humans. Methylations no… Show more

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Cited by 3 publications
(5 citation statements)
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“…Lower levels of SAM in the liver under MCD have been reported in mice and rats 3,34 but other authors failed to show any significant changes in hepatic and brain SAM, SAH, choline, betaine and cystathionine 16 . Considering the relationship between 1-carbon metabolism and circadian rhythms 17,3538 and the gene expression results reported here, these discrepancies may originate from the failure to control the time of day at which these metabolites were measured.…”
Section: Resultsmentioning
confidence: 66%
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“…Lower levels of SAM in the liver under MCD have been reported in mice and rats 3,34 but other authors failed to show any significant changes in hepatic and brain SAM, SAH, choline, betaine and cystathionine 16 . Considering the relationship between 1-carbon metabolism and circadian rhythms 17,3538 and the gene expression results reported here, these discrepancies may originate from the failure to control the time of day at which these metabolites were measured.…”
Section: Resultsmentioning
confidence: 66%
“…The data on Mat2a prompted us to probe our dataset for other genes involved in 1-carbon metabolism, which we have previously shown is enriched with rhythmically expressed genes in the liver 17 . Out of a list of 49 genes coding for enzymes and transporters involved in 1C metabolism, 27 genes had a BICW>0.8: 7 were classified as non-rhythmic in both conditions (Aldh1l2, Mtap, Ftcd, Sms, Mthfsd, Slc25a26, Mthfd1), 1 lost rhythm in MCD-fed liver (Srm), 4 gained rhythms in MCD-fed liver (Mat2b – the regulatory beta subunit of methionine adenosyltransferase 31,32 , Cth, Chdh, Tyms), 13 had identical rhythms in both condition (Slc19a1, Mtrr, Bhmt2, Slc25a32, Dhfr, Mthfd1l, Bhmt, Ahcy, Fpgs, Amd2, Gart, Tat, Atic) and 2 had changed rhythms (Mat2a, Cbs) (Supplemental Data 2).…”
Section: Resultsmentioning
confidence: 99%
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