2020
DOI: 10.1016/j.tox.2020.152463
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Methyl parathion causes genetic damage in sperm and disrupts the permeability of the blood-testis barrier by an oxidant mechanism in mice

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Cited by 34 publications
(15 citation statements)
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“…The authors coadministred methyl parathion with α-tocopherol, an antioxidant, and observed no biotin infiltration in the adluminal compartment of the seminiferous tubules, whereas in the absence of this antioxidant, permeability of the BTB was observed. The BTB permeability is regulated, among other factors, by tight, adherent and gap junctions present in Sertoli cells, thus indicating a possible toxic mechanism of methyl parathion through impairments in these cells and/or their junctions [48]. In accordance with the previous study, Pisani et al (2016) demonstrated stiffeness of the BTB junctions after exposure to carbendazim, a carbamate fungicide, consequently affecting germ cell migration [49].…”
Section: Sertoli Cellssupporting
confidence: 83%
“…The authors coadministred methyl parathion with α-tocopherol, an antioxidant, and observed no biotin infiltration in the adluminal compartment of the seminiferous tubules, whereas in the absence of this antioxidant, permeability of the BTB was observed. The BTB permeability is regulated, among other factors, by tight, adherent and gap junctions present in Sertoli cells, thus indicating a possible toxic mechanism of methyl parathion through impairments in these cells and/or their junctions [48]. In accordance with the previous study, Pisani et al (2016) demonstrated stiffeness of the BTB junctions after exposure to carbendazim, a carbamate fungicide, consequently affecting germ cell migration [49].…”
Section: Sertoli Cellssupporting
confidence: 83%
“…In our analysis, a substantial reduction of several semen parameters emerged, with a significant reduction of ejaculate volume, sperm count and concentration, confirming their negative effects on human spermatogenesis. Generating reactive oxygen species, OPs alter the physiological function of the blood–testis barrier (Urióstegui‐Acosta et al., 2020), producing covalent bonds with the occludens zone 2 (ZO2) (Ortega‐Olvera et al., 2018). The higher mean value of seminal pH in exposed men showed in our analysis is an indirect sign of this process.…”
Section: Discussionmentioning
confidence: 99%
“…They are excellent insecticides, although adverse effects can also occur in humans after exposure. OPs have also shown a worsening impact on fertility, altering the regular function of the blood-testis barrier in mice through oxidative stress, 82 forming covalent bonds with the zonula occludens-2 protein (ZO2). 83 The effect of OPs on semen quality emerged through a recent meta-analysis, where we demonstrated a decline in almost all parameters considered.…”
Section: Discussionmentioning
confidence: 99%