Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids

Monastero, Roberto; García‐Serrano, Sara; Lago-Sampedro, Ana; Rodríguez‐Pacheco, Francisca; Colomo, Natalia; Morcillo, Sonsoles; Martín‐Núñez, Gracia María; Gómez‐Zumaquero, J. M.; Garcı́a-Fuentes, Eduardo; Soriguer, Federico; Rojo-Martínez, Gemma; García‐Escobar, Eva

doi:10.1007/s00394-015-1115-7

Cited by 16 publications

(9 citation statements)

References 55 publications

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“…Moreover, Monastero et al analyzed the dietary FA-mediated epigenetic regulation induced by the Vascular Endothelial Growth Factor B (VEGF-B) in adipose tissue of rats and in 3 T3-L1 cell lines [50]. Rats fed with coconut oil presented higher levels of VEGF-B expression and levels of protein, which was associated with the methylation levels of the promoter.…”

Section: Resultsmentioning

confidence: 99%

“…Rats fed with coconut oil presented higher levels of VEGF-B expression and levels of protein, which was associated with the methylation levels of the promoter. Rats fed sunflower oil showed the lowest levels of VEGF-B while higher VEGF-B levels were associated with IR and T2D, as well as an impaired lipid metabolism [50].…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the effects of n-3 PUFA on the DNA methylation status, a possible mechanism that has been proposed is that n-3 PUFA can promote the conversion from C to 5mC conducted by DNA methyltransferases (DNMTs) by enhancing the expression of DNMTs and consequently influence DNA methylation [20]. Furthermore, a potential interaction between n-3 PUFA and MeCP2 (methyl CpG binding protein 2) has been proposed, mainly in promoter regions, and consequently could be associated with the regulation of gene expression [50]. Another possible mechanism by which n-3 PUFAs can affect methylation is that these FA are natural ligands of some transcriptional factors, such as PPAR γ [51].…”

Section: Discussionmentioning

confidence: 99%

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Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

et al. 2019

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Background Chronic illnesses like obesity, type 2 diabetes (T2D) and cardiovascular diseases, are worldwide major causes of morbidity and mortality. These pathological conditions involve interactions between environmental, genetic, and epigenetic factors. Recent advances in nutriepigenomics are contributing to clarify the role of some nutritional factors, including dietary fatty acids in gene expression regulation. This systematic review assesses currently available information concerning the role of the different fatty acids on epigenetic mechanisms that affect the development of chronic diseases or induce protective effects on metabolic alterations. Methods A targeted search was conducted in the PubMed/Medline databases using the keywords “fatty acids and epigenetic”. The data were analyzed according to the PRISMA-P guidelines. Results Consumption fatty acids like n-3 PUFA: EPA and DHA, and MUFA: oleic and palmitoleic acid was associated with an improvement of metabolic alterations. On the other hand, fatty acids that have been associated with the presence or development of obesity, T2D, pro-inflammatory profile, atherosclerosis and IR were n-6 PUFA, saturated fatty acids (stearic and palmitic), and trans fatty acids (elaidic), have been also linked with epigenetic changes. Conclusions Fatty acids can regulate gene expression by modifying epigenetic mechanisms and consequently result in positive or negative impacts on metabolic outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fatty acids, epigenetic mechanisms and chronic diseases: a systematic review

et al. 2019

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“…The effect of linoleic acid on angiogenesis modulation is contradictory, since both pro- and antiangiogenic roles have been described for this fatty acid in several models [167,168,169,170]. An interesting study showed that in vivo and in vitro treatments with linoleic acid produced an increase in the DNA methylation level of the VEGF-B promoter, which translated into lower levels of expression of the VEGF-B gene [171].…”

Section: Other Components Of the MD With Angiopreventive Potentialmentioning

confidence: 99%

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer

et al. 2019

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Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention strategy. In this review, we focus on natural bioactive compounds derived from the main foods included in the Mediterranean diet that display anti-angiogenic activity, as well as their possible use as angiopreventive agents.

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“…VEGF-B is highly expressed in a number of metabolically active tissues and, consistent with its tissue distribution, has been shown to both modulate metabolic processes (e.g., fatty acid uptake and oxidation) and be regulated by the PPAR-␥ coactivator-1␣/ estrogen-related receptor-␣ axis (10,20). Nutrient levels have also been shown to influence epigenetic changes, which ultimately regulate the expression of VEGF-B; different dietary fatty acids have been shown to affect the methylation status of the VEGF-B promoter, influencing both mRNA and protein expression of VEGF-B (22). In addition, VEGF-B appears to exert a cardioprotective role, as evidenced by VEGF-B-induced preservation of cardiac function after a myocardial infarction (16).…”

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confidence: 99%