Methylcobalamin Improves Nerve Conduction in Streptozotocin-Diabetic Rats Without Affecting Sorbitol and Myo-Inositol Contents of Sciatic Nerve

Sonobe, Masanobu; Yasuda, Hitoshi; Hatanaka, I; Terada, Masahiko; Yamashita, Michiko; Kikkawa, Ryuichi; Shigeta, Yukio

doi:10.1055/s-2007-1010925

Cited by 18 publications

(15 citation statements)

References 5 publications

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“…(16) Studies have shown that high doses of methylcobalamin improved nerve conduction in streptozotocin-diabetic rats. (17) This was again demonstrated in experimental acrylamide neuropathy, where high doses of methylcobalamin were associated with a significant increase in the rate of motor nerve fibre regeneration. (18) This may be the mechanism through which methylcobalamin acts to modify and treat the underlying pathophysiology of peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 85%

Vitamin B supplementation for diabetic peripheral neuropathy

Jayabalan¹,

Low²

2016

smedj

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Vitamin B 12 deficiency has been associated with significant neurological pathology, especially peripheral neuropathy. This review aims to examine the existing evidence on the effectiveness of vitamin B 12 supplementation for the treatment of diabetic peripheral neuropathy. A search of PubMed and the Cochrane Central Register of Controlled Trials for all relevant randomised controlled trials was conducted in December 2014. Any type of therapy using vitamin B 12 or its coenzyme forms was assessed for efficacy and safety in diabetics with peripheral neuropathy. Changes in vibration perception thresholds, neuropathic symptoms and nerve conduction velocities, as well as the adverse effects of vitamin B 12 therapy, were assessed. Four studies comprising 363 patients met the inclusion criteria. This review found no evidence that the use of oral vitamin B 12 supplements is associated with improvement in the clinical symptoms of diabetic neuropathy. Furthermore, the majority of studies reported no improvement in the electrophysiological markers of nerve conduction.

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Section: Discussionmentioning

confidence: 85%

Vitamin B supplementation for diabetic peripheral neuropathy

Jayabalan¹,

Low²

2016

smedj

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“…Previous studies showed that high doses of MeCbl improved nerve conduction in either patients with diabetic neuropathy [12–14], streptozotocin-diabetic rats [15], or experimental acrylamide neuropathy [16]. Morphological and histological evidence confirmed that a long-term administration of MeCbl promoted the synthesis and regeneration of myelin [37].…”

Section: Mechanisms Underlying the Analgesic Of Mecblmentioning

confidence: 79%

“…MeCbl also has neuronal protection including promoting injured nerve and axonal regeneration [9, 10] and confronting against glutamate-induced neurotoxicity [9, 11]. In addition, MeCbl improved nerve conduction in either patients of diabetic neuropathy [12–14] or streptozotocin-diabetic rats [15] and experimental acrylamide neuropathy [16]. MeCbl also improved visual function [17], rheumatoid arthritis [18], Bell's palsy, and sleep-wake rhythm disorder [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Methylcobalamin: A Potential Vitamin of Pain Killer

Zhang

Han

et al. 2013

Neural Plasticity

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Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCbl may have potential analgesic effects in experimental and clinical studies. For example, MeCbl alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. MeCbl improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons. This review aims to summarize the analgesic effect and mechanisms of MeCbl at the present.

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“…Motor conduction velocities calculated from latencies of M waves recorded in the hind limbs of rats have commonly been used to assess motor function in experimental peripheral neuropathies. 2,3,11,13,14,16,18,24,30,35,38,41,43 H reflexes can provide substantial information about functionally important features of peripheral sensory nerves and their central synaptic connections. Meinck 29 first described H reflexes in the foot muscles of rats, stimulated from the tibial nerve.…”

mentioning

confidence: 99%