Methylene tetrahydrofolate reductase C677T polymorphism in Korean livedoid vasculopathy patients

Cho, Soyun

doi:10.1016/j.jaad.2020.05.158

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…After the extensive literature search, 53 articles were found in PubMed and Embase databases that concern genetic variants in LV patients. By carefully reviewing the full texts of these 53 articles, 30 were enrolled that complied with the inclusion and exclusion criteria (Table 1 ) 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 . A total of 265 patients, of whom 78 were male (29.43%) and 187 were female (70.57%) giving a female to male ratio of 2.4:1, were tested for at least one out of the following six genetic variants, MTHFR C677T and A1298C, PAI‐1 ‐675 4G/5G and A844G, and Prothrombin G20210A and Factor V G1691A.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen articles presented LV patients that were examined for MTHFR C677T, 4 , 5 , 6 , 9 , 10 , 11 , 15 , 16 , 23 , 25 , 26 , 30 , 32 although one article referred vaguely to its heterozygosity or homozygosity. 9 A total of 129 patients were tested for MTHFR C677T, of which 46 had the heterozygous CT genotype (35.66%) and 25 had the homozygous TT genotype (19.38%).…”

Section: Resultsmentioning

confidence: 99%

“…In Asia, there were 11 studies or case reports from eight countries including China, 4 Japan, 11 Singapore, 12 Lebanon, 15 , 16 Turkey, 7 , 20 , 31 India, 26 South Korea, 6 and Afghanistan. 29 A total of 115 LV patients, of whom 36 were male (31.30%) and 79 were female (68.70%), with a mean age of 27.26 years were evaluated.…”

Section: Resultsmentioning

confidence: 99%

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Livedoid vasculopathy and its association with genetic variants: A systematic review

Gao

Jin

2021

International Wound Journal

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Livedoid vasculopathy (LV) is considered a disease of hypercoagulability. Association of LV with genetic variants is poorly characterised and large‐scale genetic association studies have not been performed. The aim of the study was to systematically review variants in LV patients and to analyse the available clinical data. A systematic search of the literature in PubMed and Embase databases was performed to identify articles investigating genetic variation in LV patients. Thirty studies or case reports were identified that reported 265 LV patients tested for at least one out of six genetic variations. Among them, PAI‐1 ‐675 4G/5G was the most common, accounting for 85.26% (81/95). Heterozygous 4G/5G was the major genotype. PAI‐1 A844G, MTHFR C677T, and MTHFR A1298C were the second, third, and fourth most common variants in LV patients. Prothrombin G20210A and Factor V G1691A were mainly present in LV patients from Europe, North America, and South America. This review highlights the associations between LV and genetic variants. The distribution of variants may be geographically or ethnicity dependent; however, large sample case‐control studies are needed to clarify associations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Livedoid vasculopathy and its association with genetic variants: A systematic review

Gao

Jin

2021

International Wound Journal

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“…Anticoagulation is the most commonly reported treatment for LV, providing further support for its procoagulant pathogenesis. Antiplatelet therapies have demonstrated benefit in some case series, and low-dose tissue plasminogen activator (tPA) has been shown to improve tissue Lee and Cho, 2021 75 Retrospective case series 28 patients with biopsy-proven LV vs 69 controls CSVV, cutaneous small vessel vasculitis; IL, interleukin; LV, livedoid vasculopathy; PAI-1, plasminogen activator inhibitor-1.…”

Section: Hypercoagulabilitymentioning

confidence: 99%

Livedoid vasculopathy: A review with focus on terminology and pathogenesis

et al. 2022

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Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.

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Amiodarone-induced cutaneous leukocytoclastic vasculitis: a case report and a review of the literature

Algan

Agirgol

et al. 2022

Clin Rheumatol

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Methylene tetrahydrofolate reductase C677T polymorphism in Korean livedoid vasculopathy patients

Cited by 5 publications

References 5 publications

Livedoid vasculopathy and its association with genetic variants: A systematic review

Livedoid vasculopathy and its association with genetic variants: A systematic review

Livedoid vasculopathy: A review with focus on terminology and pathogenesis

Amiodarone-induced cutaneous leukocytoclastic vasculitis: a case report and a review of the literature

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