Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase

Rasool

Natural Product Communications

et al. 2019

Self Cite

Nebrodenside A was isolated from the plant Dodonaea viscosa and its chemical structure was elucidated by spectroscopic methods. Molecular docking simulation predicted its strong ability to be tested as a potential anti-inflammatory compound. Carrageen-induced paw model and formalin test were utilized for the assessment of anti-inflammatory and analgesic potential. Nebrodenside A was found to be significantly active in reducing inflammation, when compared with diclofenac as a standard drug. Similarly, the compound also possesses substantial analgesic activity in the formalin-induced writhing test. Thus, nebrodenside A revealed a robust potential to be developed as a possible leading medicinal agent for better management of pain and inflammation.

“…The identification of the plant and extraction, fractionation, and isolation of the secondary metabolites were reported. 1…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Computational Evaluation and Anti-inflammatory and Analgesic Activities of Nebrodenside A Isolated From Dodonaea viscosa

Rasool

Natural Product Communications

et al. 2019

Self Cite

“…Identification of compounds was based on retention times, accurate mass measurements, MS/MS data, exploration of specific spectral libraries and public repositories for MS-based metabolomic analysis (MassBank MoNA, MassBank NORMAN, PubChem), and comparison with data reported in the literature [12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Lc-esi/ltqorbitrap/msmentioning

confidence: 99%

Phytochemical Profile of Capsicum annuum L. cv Senise, Incorporation into Liposomes, and Evaluation of Cellular Antioxidant Activity

et al. 2020

Overproduction of oxidants in the human body is responsible for oxidative stress, which is associated with several diseases. High intake of vegetables and fruits can reduce the risk of chronic diseases, as they are sources of bioactive compounds capable of contrasting the free radical effects involved in cancer, obesity, diabetes, and neurodegenerative and cardiovascular diseases. Capsicum annuum L. cv Senise is a sweet pepper that is grown in the Basilicata region (Italy). It is an important source of polyphenols, carotenoids, and capsinoids and can play a key role in human health. In this study, an ethanol extract was obtained from C. annuum dried peppers and the analysis of the phytochemical composition was performed by LC-ESI/LTQ Orbitrap/MS. The extract was incorporated into liposomes, which showed small size (~80 nm), good homogeneity, negative surface charge, and good stability in storage. The biological activity of the extract was evaluated in the human hepatoma (HepG2) cell line, used as model cells. The extract showed no cytotoxic activity and reduced the intracellular reactive oxygen species (ROS) level in stressed cells. The antioxidant activity was further improved when the extract was loaded into liposomes. Moreover, the extract promoted the expression of endogenous antioxidants, such as catalase, superoxide dismutase, and glutathione peroxidase through the Nrf-2 pathway evaluated by RT-PCR.

“…6 Recently, Anis and Ali discovered methylenebis(santin) from the shrub Dodonaea viscosa (Figure 1). 7…”

Section: Introductionmentioning

confidence: 99%

Facile Formation of Methylenebis(chalcone)s through Unprecedented Methylenation Reaction. Application to Antiparasitic and Natural Product Synthesis

Thévenin¹,

Mouray²,

Grellier³

et al. 2014

Eur J Org Chem

The formation of methylenebis(chalcone)s has been discovered during deprotection with methoxymethyl groups from trihydroxychalcones. Studies on this methylenation reaction led to a mechanism hypothesis that was extended to other chalcones and to dihydrochalcone, acetophenone, benzophenone and flavone derivatives. This new method was applied to the rapid synthesis of natural product piperanduncin C. These original methylenebis compounds were also evaluated for their antiparasitic activity.