Methylglyoxal in combination with 5-Fluorouracil elicits improved chemosensitivity in breast cancer through apoptosis and cell cycle inhibition

Ghosh, Sumana; Pal, Aparajita; Ray, Manju

doi:10.1016/j.biopha.2019.108855

Cited by 21 publications

(10 citation statements)

References 36 publications

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“… Ghosh et al. (2019) recently studied the anticancer effect of the combination of methylglyoxal, an agent with a well-established anticarcinogenic effect and 5-fluorouracil (5-FU), an antineoplastic agent commonly used for several types of cancer, for breast cancer treatment.…”

Section: Oncological Preclinical Studies Based On Combination Modelsmentioning

confidence: 99%

“…This research group evaluated the effect of this drug combination both in vitro using MCF-7 breast cancer cells and in vivo and successfully found synergism using the Chou-Talalay theorem. In vivo studies revealed that EAC (Ehrlich Ascites Carcinoma) bearing mice and BALB/c mouse 4T1 breast tumor models exhibited tumor regression and fewer side effects when treated with this combination compared to single agents ( Ghosh et al., 2019 ).…”

Section: Oncological Preclinical Studies Based On Combination Modelsmentioning

confidence: 99%

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Evaluation of synergism in drug combinations and reference models for future orientations in oncology

Duarte

Vale

2022

Current Research in Pharmacology and Drug Discovery

118

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Section: Oncological Preclinical Studies Based On Combination Modelsmentioning

confidence: 99%

Section: Oncological Preclinical Studies Based On Combination Modelsmentioning

confidence: 99%

Evaluation of synergism in drug combinations and reference models for future orientations in oncology

Duarte

Vale

2022

Current Research in Pharmacology and Drug Discovery

118

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“…Despite the success of these agents in the treatment of BC, emergence of drug‐resistance or intolerable toxicities remain of the major limitations (Waks & Winer, 2019). Accordingly, developing combinations of chemotherapeutic agents with safe and well‐tolerated herbal products remains an exciting approach to achieve additive or synergistic killing of cancer cells while potentially using the chemotherapy at lower dose to reduce its side effects (Ghosh, Pal, & Ray, 2019).…”

Section: Introductionmentioning

confidence: 99%

The natural isoflavone Biochanin‐A synergizes 5‐fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid‐phase carcinoma model

Mahmoud

Abdollah

El-Sesy

et al. 2022

Phytotherapy Research

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Isoflavones are considered one of the most extensively studied plant-derived phytoestrogenic compounds. Of these, Biochanin A (Bio-A), a natural isoflavone abundant in cabbage, alfalfa, and red clover, has drawn a lot of attention. As reported in multiple studies, Bio-A possesses a promising anticancer activity against estrogen receptor-positive (ER+) breast cancer. The current study investigated the working hypothesis that Bio-A could synergistically enhance the potency of 5-fluorouracil(5-FU) in ER+ breast cancer. The hypothesis was tested both in vitro on hormone receptor-positive (MCF-7) and triple-negative breast cancer cells (MDA-MB231).Additionally, in vivo studies were performed in the Ehrlich solid-phase carcinoma mouse model. The in vitro cytotoxicity studies revealed that Bio-A synergistically increased the potency of 5-FU in both MCF-7 and MDA-MB231 cell lines. The synergistic effect of 5-FU/Bio-A combination was verified in vivo. The combination therapy (where 5-FU was used at one fourth its full dose) led to a significant 75% reduction in tumor volume after two treatment cycles. This was in addition to producing a significant 2.1-fold increase in tumor necrosis area% compared to mocktreated control. In conclusion, the current study presents the first preclinical evidence

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“…Recently, various natural products have been discovered and tested as anti-BC agents. These natural products are viridiflorol, verminoside, novel phloroglucinol derivatives, genistein, vulpinic acid, calcitrinone A, kaempferol, protopanaxadiol, thymoquinone, arctigenin, glycyrrhizin, 25-OCH3-PPD, oridonin, apigenin, wogonin, fisetin, curcumin, berberine, cimigenoside, and resveratrol [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. These natural products are alkaloids, antioxidants, phenolic compounds, flavonoids, and polyphenols in nature, and are obtained from herbal products and vegetables.…”

Section: Introductionmentioning

confidence: 99%

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

et al. 2022

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Breast cancer (BC) is the second leading cause of death among women, and it has become a global health issue due to the increasing number of cases. Different treatment options, including radiotherapy, surgery, chemotherapy and anti-estrogen therapy, aromatase inhibitors, anti-angiogenesis drugs, and anthracyclines, are available for BC treatment. However, due to its high occurrence and disease progression, effective therapeutic options for metastatic BC are still lacking. Considering this scenario, there is an urgent need for an effective therapeutic strategy to meet the current challenges of BC. Natural products have been screened as anticancer agents as they are cost-effective, possess low toxicity and fewer side effects, and are considered alternative therapeutic options for BC therapy. Natural products showed anticancer activities against BC through the inhibition of angiogenesis, cell migrations, proliferations, and tumor growth; cell cycle arrest by inducing apoptosis and cell death, the downstream regulation of signaling pathways (such as Notch, NF-κB, PI3K/Akt/mTOR, MAPK/ERK, and NFAT-MDM2), and the regulation of EMT processes. Natural products also acted synergistically to overcome the drug resistance issue, thus improving their efficacy as an emerging therapeutic option for BC therapy. This review focused on the emerging roles of novel natural products and derived bioactive compounds as therapeutic agents against BC. The present review also discussed the mechanism of action through signaling pathways and the synergistic approach of natural compounds to improve their efficacy. We discussed the recent in vivo and in vitro studies for exploring the overexpression of oncogenes in the case of BC and the current status of newly discovered natural products in clinical investigations.

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Methylglyoxal in combination with 5-Fluorouracil elicits improved chemosensitivity in breast cancer through apoptosis and cell cycle inhibition

Cited by 21 publications

References 36 publications

Evaluation of synergism in drug combinations and reference models for future orientations in oncology

Evaluation of synergism in drug combinations and reference models for future orientations in oncology

The natural isoflavone Biochanin‐A synergizes 5‐fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid‐phase carcinoma model

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

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