Methylmalonate Excretion in a Patient with Pernicious Anemia

La, Barness; Young, D.G.; Wj, Mellman; Sb, Kahn; Wj, Williams

doi:10.1056/nejm196301172680309

Cited by 85 publications

(13 citation statements)

References 8 publications

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“…In this series an increased excretion of methylmalonic acid was found only in vitamin B12 deficient conditions; this agrees with the findings of Cox and White (1962) and Barness et al (1963). It is of interest that the low serum vitamin Bl, levels associated with folate deficiency do not lead to an increased excretion of methylmalonic acid.…”

Section: Discussionsupporting

confidence: 92%

Value of Estimating Methylmalonic Acid Excretion in Anaemia

Green¹,

Pegrum²

1968

BMJ

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Section: Discussionsupporting

confidence: 92%

Value of Estimating Methylmalonic Acid Excretion in Anaemia

Green¹,

Pegrum²

1968

BMJ

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“…Propionate metabolism in cells cultured from a patient with methylmalonic acidemia 219 mainder of the effluent, when reextracted with ether and subjected to two dimensional chromatography on paper [2], confirmed the identification of the compounds in the original radiochromatograms.…”

Section: Methodsmentioning

confidence: 67%

Propionate Metabolism in Cells Cultured from a Patient with Methylmalonic Acidemia

et al. 1969

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“…Plasma homocysteine levels were not different in patients with AMI compared to controls. It is known that the concentrations of homocysteine in serum and plasma are elevated in both folate and vitamin B 12 deficiencies, whereas MMA in serum, plasma or urine is a specific marker of vitamin B 12 function [3] . From that point of view, it is possible that deficiency of vitamin B 12 at tissue level during myocardial ischemia may result in increased uMMA.…”

Section: Discussionmentioning

confidence: 99%

“…The conversion of methylmalonyl-CoA to succinyl-CoA requires vitamin B 12 , so impaired cobalamin function causes an increased concentration of extracellular MMA [3] , which thereby becomes a sensitive marker of cobalamin status [2] . Serum MMA, however, is not a specific marker of cobalamin status because its concentrations are also elevated in renal failure, thyroid disease, small-bowel bacterial overgrowth and conditions of hemoconcentration [4] .…”

Section: Introductionmentioning

confidence: 99%

Urinary Methylmalonic Acid in Patients with Acute Myocardial Infarction

Çelik

Kardeşoğlu²,

İyisoy

et al. 2009

Med Princ Pract

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Objective: To investigate urinary methylmalonic acid (uMMA) levels and their relationship with markers of myocyte necrosis and inflammation in patients with acute myocardial infarction (AMI). Subjects and Methods: The study participants consisted of 80 consecutive patients with AMI and 72 age- and sex-matched consecutive controls. Of the patients, 38 had ST segment elevation myocardial infarction (STEMI) and 42 had non-ST segment elevation. All patients with STEMI underwent fibrinolytic therapy. Routine laboratory tests included troponin-I, creatinine phosphokinase MB (CK-MB), high-sensitivity C-reactive protein (hs-CRP), vitamin B₁₂, folate, homocysteine and methylmalonic acid analyses. uMMA measurements were made by a spectrophotometric method. Results: uMMA levels were significantly higher in patients with AMI than in controls (10.1 vs. 5.2 mmol/mol creatinine, p < 0.001) and higher in patients with anterior MI compared to those with non-anterior MI (18.9 vs. 8.7 mmol/mol creatinine, p < 0.001). In addition, uMMA levels were significantly higher in patients without successful reperfusion compared to those with successful reperfusion. In patients with STEMI, a strong positive association was found between urinary MMA and plasma hs-CRP levels (r = 0.81, p < 0.001), symptom duration (r = 0.91, p < 0.001) and wall motion score (r = 0.60, p = 0.006). More importantly, a strong positive association was observed between uMMA and the size of myocardial infarction in patients without successful reperfusion (for CK-MB r = 0.81, p = 0.013; for wall motion score r = 0.82, p = 0.012). Conclusion: uMMA levels were elevated in patients with AMI and, as such, may be a candidate biochemical indicator of larger infarct size and enhanced inflammation in patients with AMI.

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Methylmalonate Excretion in a Patient with Pernicious Anemia

Cited by 85 publications

References 8 publications

Value of Estimating Methylmalonic Acid Excretion in Anaemia

Value of Estimating Methylmalonic Acid Excretion in Anaemia

Propionate Metabolism in Cells Cultured from a Patient with Methylmalonic Acidemia

Urinary Methylmalonic Acid in Patients with Acute Myocardial Infarction

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