Methylmercury and Polycyclic Aromatic Hydrocarbons in Mediterranean Seafood: A Molecular Anthropological Perspective

Giovanni, Andrea De; Giuliani, Cristina; Marini, Mauro; Luiselli, Donata

doi:10.3390/app112311179

Cited by 5 publications

(8 citation statements)

References 186 publications

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“…However, it should be considered that the seafood ingestion rate is variable among the population [80], and that an individual is simultaneously exposed to several PAH sources, from both ingestion and other routes. Furthermore, it is vital to note the emerging role of genetics in shaping individual susceptibility to PAHs [81].…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of a New Georeferenced Database on Polycyclic Aromatic Hydrocarbons in Western and Central Mediterranean Seafood

et al. 2022

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The aim of this work was to collect and harmonize the results of several studies achieved over the years, in order to obtain a database of georeferenced observations on polycyclic aromatic hydrocarbons (PAHs) in Western and Central Mediterranean seafood. For each observation, some information on the taxonomy and the ecology of the sampled species are reported, as well as details on the investigated hydrocarbon, and spatial and temporal information on sampling. Moreover, two health risk indexes were calculated for each record and included in the database. Through several statistical methods, we conducted a meta-analysis of the data on some of the species in this database, identifying trends that could be related to the biology of the investigated organisms, as well as to the physico-chemical properties of each hydrocarbon and to the oceanographic characteristic of this part of the Mediterranean. The analysis of the data showed that, at a consumption rate like the one typical of the Italian population, seafood caught from the area considered in the present work seems to pose a minimal risk to health. However, we also found evidence of an increasing trend of PAH concentrations in Mediterranean mussels, pointing to the need for constant monitoring.

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Section: Discussionmentioning

confidence: 99%

Meta-Analysis of a New Georeferenced Database on Polycyclic Aromatic Hydrocarbons in Western and Central Mediterranean Seafood

et al. 2022

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“…In mixtures, PAHs induce toxicity following the concentration-addition model; therefore, the chemical activity concept that reflects the mixture potential to cause baseline toxicity might be a way to evaluate the occurrence of PAH-DNA adducts in the contaminated environments . In addition, similar correlations for Hg and PAHs in all low-mass and most high-mass adducts (Figure ) indicate possible joint effects of Hg and PAHs on DNA. , …”

Section: Discussionmentioning

confidence: 99%

“…56 In addition, similar correlations for Hg and PAHs in all low-mass and most high-mass adducts (Figure 4) indicate possible joint effects of Hg and PAHs on DNA. 57,58 Both positive and negative correlations between the adducts (L284, L315, L319, L8, L9, L91, H154, H205, H299, H305, and H447) and metals (As, Co, Zn, Pb, Cr, Hg, and PLI), suggest effects of metal exposure on DNA modifications. As no significant negative correlations were observed among these metals (Figure S3), the multicollinearity as a reason for both positive and negative correlations can be ruled out.…”

Section: Associations Between Adducts and Contaminantsmentioning

confidence: 99%

DNA Adductomics for the Biological Effect Assessment of Contaminant Exposure in Marine Sediments

Martella

Gorokhova

Sousa

et al. 2023

Environ. Sci. Technol.

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Exposure to chemical pollution can induce genetic and epigenetic alterations, developmental changes, and reproductive disorders, leading to population declines in polluted environments. These effects are triggered by chemical modifications of DNA nucleobases (DNA adducts) and epigenetic dysregulation. However, linking DNA adducts to the pollution load in situ remains challenging, and the lack of evidence-based DNA adductome response to pollution hampers the development and application of DNA adducts as biomarkers for environmental health assessment. Here, we provide the first evidence for pollution effects on the DNA modifications in wild populations of Baltic sentinel species, the amphipod Monoporeia affinis. A workflow based on high-resolution mass spectrometry to screen and characterize genomic DNA modifications was developed, and its applicability was demonstrated by profiling DNA modifications in the amphipods collected in areas with varying pollution loads. Then, the correlations between adducts and the contaminants level (polycyclic aromatic hydrocarbons (PAHs), trace metals, and pollution indices) in the sediments at the collection sites were evaluated. A total of 119 putative adducts were detected, and some (5-me-dC, N6-me-dA, 8-oxo-dG, and dI) were structurally characterized. The DNA adductome profiles, including epigenetic modifications, differed between the animals collected in areas with high and low contaminant levels. Furthermore, the correlations between the adducts and PAHs were similar across the congeners, indicating possible additive effects. Also, high-mass adducts had significantly more positive correlations with PAHs than low-mass adducts. By contrast, correlations between the DNA adducts and trace metals were stronger and more variable than for PAHs, indicating metal-specific effects. These associations between DNA adducts and environmental contaminants provide a new venue for characterizing genome-wide exposure effects in wild populations and apply DNA modifications in the effect-based assessment of chemical pollution.

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“…The reproductive toxicity of MeHg has been confirmed in animal studies [64]. MeHg concentrations in fish increase with trophic level, size and age, as it is the result of bioaccumulation during the entire lifespan of the animal [65]. The European Commission (EC Regulation 1881/2006) limits the total Hg level allowed in seafood to 0.5-1.0 mg/kg, while no restriction exists for MeHg.…”

Section: Mehg Implementation Into the Aquatic Food Web And Its Conseq...mentioning

confidence: 95%

The Role of Microalgae in the Biogeochemical Cycling of Methylmercury (MeHg) in Aquatic Environments

et al. 2022

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Methylmercury (MeHg) is the most important and the most abundant organic Hg pollutant in the aquatic ecosystem that can affect human health through biomagnification. It is the most toxic organic Hg form, which occurs naturally and by human-induced contamination in water and is further biomagnified in the aquatic food web. MeHg is the only Hg form that accumulates in living organisms and is able to cross the blood–brain barrier, presenting an enormous health risk. Anthropogenic activity increases eutrophication of coastal waters worldwide, which promotes algae blooms. Microalgae, as primary producers, are especially sensitive to MeHg exposure in water and are an important entrance point for MeHg into the aquatic food web. MeHg assimilated by microalgae is further transferred to fish, wildlife and, eventually, humans as final consumers. MeHg biomagnifies and bioaccumulates in living organisms and has serious negative health effects on humans, especially newborns and children. Knowledge of the microalgae−MeHg interaction at the bottom of the food web provides key insights into the control and prevention of MeHg exposure in humans and wildlife. This review aims to summarize recent findings in the literature on the microalgae–MeHg interaction, which can be used to predict MeHg transfer and toxicity in the aquatic food web.

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Methylmercury and Polycyclic Aromatic Hydrocarbons in Mediterranean Seafood: A Molecular Anthropological Perspective

Cited by 5 publications

References 186 publications

Meta-Analysis of a New Georeferenced Database on Polycyclic Aromatic Hydrocarbons in Western and Central Mediterranean Seafood

Meta-Analysis of a New Georeferenced Database on Polycyclic Aromatic Hydrocarbons in Western and Central Mediterranean Seafood

DNA Adductomics for the Biological Effect Assessment of Contaminant Exposure in Marine Sediments

The Role of Microalgae in the Biogeochemical Cycling of Methylmercury (MeHg) in Aquatic Environments

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