Methylmercury in Predatory and Non-predatory Fish Species Marketed in the Amazon Triple Frontier

Silva, Stephani Ferreira da; Pereira, João Paulo Góes; Oliveira, Diomar Cavalcante; Lima, Marcelo de Oliveira

doi:10.1007/s00128-020-02862-5

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…[12,33] The presence of this biomarker of damage has been associated with the process of chromosomal elimination involved in aneuploidy, which may be related to the affinity of Hg with the sulfhydryl groups of tubulins, impairing spindle function. [7,14] In addition, micronuclei can represent fragments or entire chromosomes that failed to remain in the nucleus of daughter cells. [34] In this case, the ability to cause DNA double-strand breaks should be considered.…”

Section: Micronucleus Testmentioning

confidence: 99%

“…[ 4,5 ] More than 95% of the total Hg present in fish muscle tissue is MeHg and tends to be higher in predatory species. [ 6,7 ] Therefore, dietary consumption of contaminated food, especially fish, is the primary pathway of human exposure to MeHg.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[12,13] Mercury genotoxicity has been associated with its affinity with the sulfhydryl groups of tubulins, impairing spindle function and leading to chromosomal aberrations, and also to its ability to produce free radicals, which can cause DNA damage. [7,14] In this regard, genotoxicity tests can be used to demonstrate both aneugenic effects, such as loss or gain of chromosomes, and DNA damage, such as single and double-strand breaks. [15] Therefore, considering the MeHg tropism for the nervous system, in which we have the interaction of two different types of cells, and that neoplastic cell lines are commonly used in toxicological studies and in vitro models aiming to assess the toxicity of mercury compounds, especially in the nervous system, [16][17][18][19] the present investigation attempted to evaluate comparatively the action of MeHg in an acute in vitro exposure in two cell lines representing neurons and glia cells, to contribute to a better understanding of the steps involved in the injuries and cell death processes caused by mercury exposure.…”

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confidence: 99%

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Intracellular accumulation and DNA damage caused by methylmercury in glial cells

Sousa

Pereira

Malaquias

et al. 2022

J Biochem & Molecular Tox

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Mercury is widely used in industrial and extractive processes, and the improper disposal of waste or products containing this metal produces a significant impact on ecosystems, causing adverse effects on living organisms, including humans. Exposure to methylmercury, a highly toxic organic compound, causes important neurological and developmental impairments. Recently, the genotoxicity of mercurial compounds has gained prominence as one of the possible mechanisms associated with the neurological effects of mercury, mostly by disturbing the mitotic spindle and causing chromosome loss. In this sense, it is important to investigate if these compounds can also cause direct damage to DNA, such as single and double‐strand breaks. Thus, the aim of this study was to investigate the cytotoxic and genotoxic potential of methylmercury in cell lines derived from neurons (B103) and glia (C6), exposed to methylmercury (MeHg) for 24 h, by analyzing cell viability, metabolic activity, and damage to DNA and chromosomes. We found that in comparison to the neuronal cell line, glial cells showed higher tolerance to MeHg, and therefore a higher LC50 and consequent higher intracellular accumulation of Hg, which led to the occurrence of several genotoxic effects, as evidenced by the presence of micronuclei, bridges, sprouts, and chromosomal aberrations.

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Section: Micronucleus Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Intracellular accumulation and DNA damage caused by methylmercury in glial cells

Sousa

Pereira

Malaquias

et al. 2022

J Biochem & Molecular Tox

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“…In addition to marine fish, the researchers also investigated freshwater fish, and the results showed the same trend [ 43 , 44 ]. Hg concentration is high in some long-living and predatory fish that simultaneously have higher opportunities for accumulating Hg [ 45 , 46 , 47 ].…”

Section: Bio-accumulation Species-specific and Geographical Differenc...mentioning

confidence: 99%

Mercury Contamination in Fish and Its Effects on the Health of Pregnant Women and Their Fetuses, and Guidance for Fish Consumption—A Narrative Review

Chen

Dong

2022

IJERPH

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As a principal source of long-chain omega-3 fatty acids (3FAs), which provide vital health benefits, fish consumption also comes with the additional benefit of being rich in diverse nutrients (e.g., vitamins and selenium, high in proteins and low in saturated fats, etc.). The consumption of fish and other seafood products has been significantly promoted universally, given that fish is an important part of a healthy diet. However, many documents indicate that fish may also be a potential source of exposure to chemical pollutants, especially mercury (Hg) (one of the top ten chemicals or groups of chemicals of concern worldwide), and this is a grave concern for many consumers, especially pregnant women, as this could affect their fetuses. In this review, the definition of Hg and its forms and mode of entrance into fish are introduced in detail and, moreover, the bio-accumulation of Hg in fish and its toxicity and action mechanisms on fish and humans, especially considering the health of pregnant women and their fetuses after the daily intake of fish, are also reviewed. Finally, some feasible and constructive suggestions and guidelines are recommended for the specific group of pregnant women for the consumption of balanced and appropriate fish diets in a rational manner.

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Methylmercury in Fish from the Amazon Region—a Review Focused on Eating Habits

Gimenes

Penteado

Santos

et al. 2021

Water Air Soil Pollut

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Methylmercury in Predatory and Non-predatory Fish Species Marketed in the Amazon Triple Frontier

Cited by 6 publications

References 27 publications

Intracellular accumulation and DNA damage caused by methylmercury in glial cells

Intracellular accumulation and DNA damage caused by methylmercury in glial cells

Mercury Contamination in Fish and Its Effects on the Health of Pregnant Women and Their Fetuses, and Guidance for Fish Consumption—A Narrative Review

Methylmercury in Fish from the Amazon Region—a Review Focused on Eating Habits

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