Methylmercury-induced alterations in lung and pulmonary surfactant properties of adult mice

Das, R. M.; Ahmed, Mushtaq; Oulton, M.; Mantsch, Henry H.; Tsubai, Takayoshi; Scott, J. E.

doi:10.1016/s0009-3084(97)00072-8

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Earlier studies have reported that selenium and / or vitamin E protect against mercury toxicity (Beyrouty and Chan 2006;Kalender et al 2013;Deepmala et al 2013;Joshi et al 2014). There are other studies, which reported that heavy metals caused histopathological alterations in the lung tissue (Das et al 1997;Yoshida et al 1999;Onarlioglu et al 1999;Kaczynska et al 2011;El Bamby et al 2012;Blum et al 2014). In the present study, oral exposure to mercuric chloride caused histopathological changes like edema, hemorrhage, infiltration of inflammatory cells, interalveolar septa thickening, degeneration in alveoli and bronchioles, fibrosis were observed in the lung tissue.…”

Section: Discussionsupporting

confidence: 59%

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Çelikoğlu

Aslantürk

Kalender

2015

Braz. arch. biol. technol.

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Section: Discussionsupporting

confidence: 59%

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Çelikoğlu

Aslantürk

Kalender

2015

Braz. arch. biol. technol.

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“…The acute effect of the inhalation of mercury vapors can be severe lung inflammation, and it was proved in the in vitro experiments that Hg 2+ and CH 3 Hg + have adverse effect on the synthesis of the lung surfactant in the alveoli. 19 In the attempt to generalize different mechanisms of mercury toxicity, an important question arises: how do different forms of mercury cross the cell membrane; i.e., what is the interaction of Hg 2+ and CH 3 Hg + with the natural membrane components, such as phospholipids and proteins. 20 One of the hypothesis, so-called molecular mimicry, 21 holds that the structure of the complex formed by Hg 2+ and two molecules of cysteine is very similar to its oxidized form, cystidine, and CH 3 Hg + bound to one molecule of cysteine resembles the molecule of the amino acid, methionine; therefore, in both cases mercury in the form of complexes can cross the bilayer via the appropriate protein channels, enabling in this way the active transport of amino acids inside the cell.…”

Section: Introductionmentioning

confidence: 99%

“…Water channels are abundant in erythrocytes and in cells of salivary glands; therefore, this effect can be crucial in explaining the Hg toxicity toward these cells. The acute effect of the inhalation of mercury vapors can be severe lung inflammation, and it was proved in the in vitro experiments that Hg 2+ and CH 3 Hg + have adverse effect on the synthesis of the lung surfactant in the alveoli …”

Section: Introductionmentioning

confidence: 99%

Search for the Molecular Mechanism of Mercury Toxicity. Study of the Mercury(II)−Surfactant Complex Formation in Langmuir Monolayers

Broniatowski

Dynarowicz-Łątka

2009

J. Phys. Chem. B

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Surface pressure and electric surface potential measurements complemented with Brewster angle microscope observations have been used to study the interactions of Hg(2+) ions with selected surfactants spread in Langmuir monolayers. The chosen surfactants had the same hydrocarbon chain length (18 carbon atoms) and different polar groups, such as -COOH, -NH(2), -OH, and -SH, which can be found in natural cells. Our results indicate that Hg(2+) interacts strongly not only with the -SH group, which is believed to be the main target for mercury ions, but also with -COOH and -NH(2) groups. Another important finding is that hydracid or oxoacid mercury salts interact with surfactants differently. The observed differences were explained as being due to different coordination of mercury in the respective complexes. Similar experiments as for mercury salts have also been performed for other heavy metal ions (Cd(2+), Pb(2+), and Ag(+)). It turned out that the interactions with the investigated surfactants monolayers were considerably different, which was explained by different coordination properties of the above cations. The profound changes exerted by Hg(2+) ions on Langmuir monolayers of the selected herein surfactants (multilayer formation, induction of aggregation) may be related to natural membranes and can contribute to the elucidation of the molecular mechanism of mercury toxicity.

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“…Infrared (IR) spectroscopy is a technique used traditionally for studying physical, organic and atmospheric chemistry (Jackson et al, 1997). While IR spectroscopy has been often employed in the study of isolated biological material such as proteins, lipids and membranes, only recently has the range of applications been expanded to include the study of diseased tissues (Das et al, 1997;Jackson et al, 1997;Knells et al, 1997).…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Lung cancer: occurrence and new possibilities for detection

McCrae

Shaw

Mantsch

et al. 1999

Leadership in Health Services

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Lung cancer is the leading cause of cancerrelated deaths among Canadian men and women. In Canada, an estimated 17,400 deaths and 20,500 new cases of lung cancer occurred in 1999 (National Cancer Institute of Canada, 1999). Men continue to outnumber women in terms of incidence and death due to cancer (Figure 1), including lung cancer which accounts for approximately 30 percent of all cancer deaths in men and 20 percent in women (Health Canada, 1998; National Cancer Institute of Canada, 1999).For men, the incidence of lung cancer ranks second to prostate cancer (Figure 2). For example, in 1999 there were an estimated 12,000 newly diagnosed cases of lung cancer compared to 16,600 cases of prostate cancer. Although lung cancer remains the leading cause of death among men, both incidence and mortality rates have been declining since the mid-1980s (Health Canada, 1998 National Cancer Institute of Canada, 1999).However, incidence and mortality rates of lung cancer in women continue to rise (Figure I). Interestingly, for 1999 the estimated incidence of lung cancer is less than half the incidence of breast cancer, 8,500 and 18,700, respectively (Figure 3). Yet given previously observed death rates, lung cancer will account for an estimated 6,800 deaths compared to 5,400 deaths from breast cancer (National Cancer Institute of Canada, 1999).The lifetime probability of developing lung cancer for women is 1 in 21 (National Cancer Institute of Canada, 1999). Among men, the probability of developing lung cancer during their lifetime is 1 in 11. Although cancer primarily afflicts Canadians over age 60, lung cancer is the leading cause of cancer deaths among men aged 35-84 and women aged 50 or older (Figure 4). The incidence of lung cancer among women aged 45-74 ranks second to breast cancer, and among men aged 70 or older ranks second to prostate cancer. However; lung cancer is the most common type of cancer in men aged

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Methylmercury-induced alterations in lung and pulmonary surfactant properties of adult mice

Cited by 7 publications

References 27 publications

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Vitamin E and Sodium Selenite Against Mercuric Chloride-Induced Lung Toxicity in the Rats

Search for the Molecular Mechanism of Mercury Toxicity. Study of the Mercury(II)−Surfactant Complex Formation in Langmuir Monolayers

Lung cancer: occurrence and new possibilities for detection

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