Methylotroph Infections and Chronic Granulomatous Disease

Falcone, Emilia Liana; Petts, Jennifer R.; Fasano, Mary Beth; Ford, Bradley; Nauseef, William M.; Neves, João Farela; Simões, Maria João; Tierce, Millard L.; Morena, M. Teresa de la; Greenberg, David E.; Zerbe, Christa S.; Zelazny, Adrian M.; Holland, Steven M.

doi:10.3201/eid2203.151265

Cited by 22 publications

(20 citation statements)

References 12 publications

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“…The organism was first detected in an adult patient with indolent and recurrent necrotizing lymphadenitis [ 349 ]. Subsequently, G. bethesdensis was isolated from nine patients with CGD, primarily causing lymphadenitis, but there have been two fatalities [ 350 ]. Treatment has been most effective with intravenous ceftriaxone.…”

Section: Section 3: Manifestations and Infection Unique To The Immunementioning

confidence: 99%

Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies

et al. 2017

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In today’s global economy and affordable vacation travel, it is increasingly important that visitors to another country and their physician be familiar with emerging infections, infections unique to a specific geographic region, and risks related to the process of travel. This is never more important than for patients with primary immunodeficiency disorders (PIDD). A recent review addressing common causes of fever in travelers provides important information for the general population Thwaites and Day (N Engl J Med 376:548-560, 2017 ). This review covers critical infectious and management concerns specifically related to travel for patients with PIDD. This review will discuss the context of the changing landscape of infections, highlight specific infections of concern, and profile distinct infection phenotypes in patients who are immune compromised. The organization of this review will address the environment driving emerging infections and several concerns unique to patients with PIDD. The first section addresses general considerations, the second section profiles specific infections organized according to mechanism of transmission, and the third section focuses on unique phenotypes and unique susceptibilities in patients with PIDDs. This review does not address most parasitic diseases. Reference tables provide easily accessible information on a broader range of infections than is described in the text.

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Section: Section 3: Manifestations and Infection Unique To The Immunementioning

confidence: 99%

Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies

et al. 2017

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“…He was treated with ceftriaxone and doxycycline for 15 months with significant improvement but not complete resolution of lymphadenopathy. 8 These 7 patients had fever and increased inflammatory markers for prolonged periods of time. Interestingly, recurrences of infection were a frequent occurrence even after 2 and 3 years, raising the concern that this bacterium can cause a latent infection.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 The first case was a 39-year-old man with fever and necrotizing axillary and cervical lymphadenitis, treated with doxycycline and meropenem. He had 3 recurrences in 2 years and was finally treated with ceftriaxone and doxycycline for 1 year.…”

Section: Discussionmentioning

confidence: 99%

“…The patient died as a consequence of obstructive hydrocephalus and multiorgan failure. 8 It was postulated that this slight genetic difference may represent some regional variability, with a consequent different clinical presentation and a more invasive organism. 7,8 Although the 16s rRNA analysis identified the bacteria from our patient in New York as G. bethesdensis (GenBank ID NR_043197), the specimen was not longer available to confirm this result by reanalyzing it using 1500 bp.…”

Section: Discussionmentioning

confidence: 99%

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Fulminant Sepsis Due to Granulibacter bethesdensis in a 4-Year-Old Boy With X-Linked Chronic Granulomatous Disease

Mayer

Gialanella

Munjal

et al. 2017

Pediatric Infectious Disease Journal

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Granulibacter bethesdensis is a Gram-negative bacillus described as a pathogen exclusively in patients with chronic granulomatous disease, a phagocytic disorder that impairs the ability to clear catalase-producing organisms. Granulibacter usually causes chronic and recurrent lymphadenopathies. We report the fatal case of a 4-year-old boy with chronic granulomatous disease, who presented with sepsis after a few days of abdominal pain and diarrhea.

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“…It has been mostly linked to indolent nonfatal lymphadenitis and deep neck infections in patients in North America. The infection can recur over several years by reactivation of the same strain or reinfection with different strains (3,(7)(8)(9). The first fatal infection was reported in a 10-yearold boy from Spain, who died of fulminant sepsis (10).…”

mentioning

confidence: 99%

Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis

Rebelo¹,

Ding²,

Cordeiro³

et al. 2019

Emerg. Infect. Dis.

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Methylotroph Infections and Chronic Granulomatous Disease

Abstract: Disease caused by these environmental bacteria is almost exclusively limited to patients with this condition.

Cited by 22 publications

References 12 publications

Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies

Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies

Fulminant Sepsis Due to Granulibacter bethesdensis in a 4-Year-Old Boy With X-Linked Chronic Granulomatous Disease

Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis

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