Methylphenidate in the ‘hard to wean’ patient

Johnson, Cameron J.; Auger, William R.; Fedullo, Peter F.; Dimsdale, Joel E.

doi:10.1016/0022-3999(94)00075-g

Cited by 17 publications

(8 citation statements)

References 11 publications

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“…A prospective trial of methylphenidate for negative symptoms such as anhedonia and psychomotor retardation in patients with Alzheimer's disease or vascular dementia64 reported significant improvement in symptoms scores, but did not provide response rates. Reports of successful uses of methylphenidate in the literature include treatment of lethargy and depressive symptoms in mechanically ventilated patients who are difficult to wean,75, 76 treatment of anorexia in apathetic, severely demented nursing home residents,77, and treatment of depressive symptoms in patients up to 106 years of age 78…”

Section: Resultsmentioning

confidence: 99%

Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults

Hardy

2009

The American Journal of Geriatric Pharmacotherapy

117

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Section: Resultsmentioning

confidence: 99%

Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults

Hardy

2009

The American Journal of Geriatric Pharmacotherapy

117

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“…Furthermore, for mechanically ventilated patients, Johnson et al (1995) reported considerable success in the application of methylphenidate when weaning patients from ventilators. They suggest that the results may be achieved by methylphenidate's effect on fatigue and/ or depression.…”

Section: Further Applications Of Methylphenidatementioning

confidence: 98%

Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects

Leonard¹,

McCartan²,

White³

et al. 2004

Human Psychopharmacology

210

145

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“…addition, unnecessary delays in extubation can result in increased risk for nosocomial pneumonia, Traditional antidepressants have a slow onset of action, but recent, uncontrolled reports suggest that increased duration of ICU stay, and excess hospital mortality [132]. The measurements delineated in the rapid-onset psychostimulant methylphenidate may facilitate liberation from the ventilator [123,124]. Table 2 have not proved sufficiently precise in identifying patients at increased risk for extubation fail-In summary, although tracheotomy, inspiratory muscle training, and therapy of the psychological ure.…”

Section: Treatment Of Psychological Barriers To Wean-mentioning

confidence: 99%

Controversies in Weaning from Mechanical Ventilation

Epstein

2001

J Intensive Care Med

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Invasive mechanical ventilation can successfully support the patient with acute respiratory failure, but it is associated with considerable risks. Numerous complications of invasive mechanical ventilation have been identified, and these may contribute to increased mortality. Therefore after clinical improvement has occurred, considerable emphasis is placed on expeditiously freeing the patient from the ventilator. This process of getting a patient off mechanical ventilation has been variably termed weaning, liberation, or discontinuation (terms which may be used interchangeably), and can be further divided into “readiness testing” and “progressive withdrawal.” Over the last decade, new developments in our understanding of the process of weaning have provided investigators with the tools to address a number of key questions: How should readiness for weaning (and trials of spontaneous breathing) be determined? What is the role of weaning parameters in deciding when to initiate the weaning process? What is the best mode for conducting a spontaneous breathing trial and how should the patient be monitored? What are the mechanisms for weaning (and spontaneous breathing trial) failure? What is the best technique to facilitate progressive withdrawal? What other factors can facilitate liberation from mechanical ventilation? What are the risks of extubation failure and how can extubation outcome best be predicted? What is the role for protocols in facilitating weaning from mechanical ventilation?.

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Methylphenidate in the ‘hard to wean’ patient

Cited by 17 publications

References 11 publications

Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults

Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults

Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects

Controversies in Weaning from Mechanical Ventilation

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