Methylprednisolone treatment of immunologic infertility in the male

Shulman, Joanna F.; Shulman, Sidney

doi:10.1016/s0015-0282(16)46640-9

Cited by 78 publications

(22 citation statements)

References 14 publications

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“…Two factors leading to success appear to be the significant reduction in the antibody attachment achieved by the washing technique and the bypassing of cervical mucus by IUI. It has been demonstrated that IgA is more likely to prevent sperm from passing through cervical mucus than IgG and therefore the patients with high levels of IgA attachment may represent a variety of cervical factor infertility [28].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Immunological Infertility by Sperm Washing and Intrauterine Insemination

Agarwal

1992

Archives of Andrology

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The purpose of this study is to review our experience with sperm washing and intrauterine insemination as a method to reduce the presence of sperm antibodies in serum of couples with immunological infertility. Our results support the premise that sperm washing and intrauterine insemination can diminish the level of sperm-bound immunoglobulins and can improve the chance of conception in a selected group of couples with a diagnosis of immunological infertility. Patients with >50% attachment of IgG, IgA, or both antisperm antibodies in this study had a greater chance of achieving a pregnancy. The high level of antibody attachment seen in our study appears to represent true immunological infertility and therefore is more likely to respond to therapy that reduces antibody attachment and bypasses cervical mucus.

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Section: Discussionmentioning

confidence: 99%

Treatment of Immunological Infertility by Sperm Washing and Intrauterine Insemination

Agarwal

1992

Archives of Andrology

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“…However, cortisone therapy has been suggested for cases of immunological infertility, reportedly yielding pregnan cy rates of up to 44% [18][19][20], This unclear situation prompted us to investigate the occurrence and possible impact of sperm antibodies in infertile patients with the OAT syndrome and in testicular cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Antisperm Antibodies in Patients with Carcinoma of the Testis and in Subfertile Men with Normogonadotropic Oligoasthenoteratozoospermia

Höbarth¹,

Klingler²,

Maier³

et al. 1994

Urol Int

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The incidence and the clinical relevance of sperm-reactive antibodies in sub-fertile men and in testicular cancer patients were assessed in a pilot study. The sera of 42 men with normogonadotropic oligoasthenoteratozoospermia (OAT syndrome, n = 20) or carcinoma of the testis after inguinal semicastration (n = 22) were analyzed for agglutinating antisperm antibodies using fiuorescein-labeled antiglobulin. In the group with the OAT syndrome, the incidence of sperm-reactive antibodies was only 5 %, which is comparable to that in normal fertile men. Although the incidence of 18% in the testicular cancer patients was markedly higher, only 2 of the patients in question had abnormal spermiograms, which in one case could, moreover, be explained by previous radiation therapy. In summary in this small group of patients, serum monitoring for sperm-reactive antibodies appeared to be of limited clinical relevance in patients with the OAT syndrome and in testicular cancer patients.

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“…We have recently reported the results of a large group of men who were treated in this way [73], Starting with 102 men over a 5-year period, a residual number of 71 could be evaluated fully for all the desired follow-up parameters. In this group of men, there was a success rate of 44%.…”

Section: Intermittent High-dose Methodsmentioning

confidence: 99%