Methylsulfonyl PCB and DDE metabolites and their enantioselective gas chromatographic separation in human adipose tissues, seal blubber and pelican muscle

Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime

“…Plasma levels of PCB 153 were determined by highresolution gas chromatography with electron capture detection (HRGC/mECD; Agilent Technologies 6890 Series, Palo Alto, CA, USA), Capillary Column DB-5 (0.25 mm  60 m  0.25 mm; J&W Scientific, USA 12 ).…”

Enantioselective accumulation of chiral polychlorinated biphenyls in lotus plant (Nelumbonucifera spp.)

“…There are many reports of such enantioselectivity of chiral PCBs in animal species, such as mice and rats [7], fish, dolphins [8,9], spider [10], mysids [11], rainbow trout [12], and humans [13,14]. However, the few reports of accumulation and biotransformation of chiral PCBs in autotrophic species provide conflicting evidence as to the ability of these species to biodegrade such chemicals.…”

Chirality as an Environmental Forensics Tool

“…Ringed seals formed highly nonracemic 5-MeSO 2 -PCB 149 not present in arctic cod, their major prey [260], indicating that seals formed this metabolite from enantioselective formation and/or clearance. Livers of grey seals in the Baltic Sea had much higher MeSO 2 -PCB concentrations than lung and In contrast, blubber of seals in captivity had racemic 4-MeSO 2 -PCB 149; the species was not identified in that study [243]. Changing the location of the methyl sulfone moiety results in preferential accumulation of 5-and 5 0 -MeSO 2 -PCBs in liver tissue and 4-MeSO 2 -PCBs in lung tissue, most likely from selective protein binding [7].…”

“…glaucous gulls, Larus hyperboreus) were at higher tropic levels than marine mammals based on stable nitrogen tissue analysis [241], suggesting that scavenging of seal carcasses could have led to accumulation of nonracemic POPs. Pelican tissues had nonracemic amounts of 4 0 -MeSO 2 -PCB 132 and 4-and 5-MeSO 2 -PCB 149 [243], consistent with enantioselective PCB biotransformation capacity in birds.…”

“…5 0 -MeSO 2 -PCB 132 and 5-MeSO 2 -PCB 149) enriched in lung in highly nonracemic proportions [289]. Other studies, however, targeting MeSO 2 -PCB enantiomers did not detect any [243]. In human serum, (À)-a-HBCDD was dominant, with an EF of 0.2 [290].…”