2017
DOI: 10.1016/j.ejphar.2017.06.034
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Methylsulfonylmethane is effective against gastric mucosal injury

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Cited by 32 publications
(13 citation statements)
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“…In the process of alcohol-induced gastric ulcers, the submucosa of the tissue can usually be infiltrated by inflammatory cells. Inflammatory cells are the main source of MMPs (36) and MCP-1 is closely related to inflammation (21). We found that the levels of MMP-9 and MCP-1 did not increase, and no corresponding inflammatory cells were found in the pathological sections.…”
Section: Discussionmentioning
confidence: 63%
“…In the process of alcohol-induced gastric ulcers, the submucosa of the tissue can usually be infiltrated by inflammatory cells. Inflammatory cells are the main source of MMPs (36) and MCP-1 is closely related to inflammation (21). We found that the levels of MMP-9 and MCP-1 did not increase, and no corresponding inflammatory cells were found in the pathological sections.…”
Section: Discussionmentioning
confidence: 63%
“…In contrast, reversal of Cyp2c29 expression in APAP-and CCl 4 -induced hepatotoxicity (two common models of liver injury), resulted in suppression of pro-inflammatory signaling and cytokine production by targeting NF-kB pathway [42]. Interestingly, similar anti-inflammatory effects associated with NF-kB inhibition were reported for MSM [43,44]. These findings may have a significant therapeutic value and further investigations of the MSM/CRCE interaction potential and its effects on NF-kB signaling pathway are clearly warranted.…”
Section: Discussionmentioning
confidence: 87%
“…Effect of Lycopene administration on colon tissue L-MDA, CAT and GSH of acetic acid-induced ulcerative colitis in male rats was presented in table (1).The obtained results showed significant increase L-MDA concentration with marked decreases in CAT activity and GSH concentrations in colon of acetic acid -induced ulcerative colitis in rats as compared with control normal group. However, a significant depletion of colon tissue L-MDA concentration and marked increase in CAT activity and GSH concentrations were observed after LYC treatment compared to ulcerated untreated rats.…”
Section: Resultsmentioning
confidence: 94%
“…These lead to production of superoxide anion and initiation of a cascade for the production of various reactive species. Malondialdehyde (MDA) is one of the end products of the lipid peroxidation procedure and increasing in the free radical activity causes overproduction of MDA (Amirshahrokhi and Khalili, 2017). Endogenous antioxidant defenses against reactive oxygen species (ROS) production even in low concentrations influence on two main types: (1) enzymatic (CAT) and (2) non-enzymatic (GSH) (Halliwell and Gutteridge, 2007).…”
Section: Introductionmentioning
confidence: 99%