Metronidazole Loaded Microspheres and Membranes of Dibutyrylchitin: Preparation and Drug Release Investigation

Błasińska, A.; Szosland, Lidia; Krucińska, Izabella

doi:10.1533/9781845694104.5.296

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2011

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“…Mentioned biopolymers show full biocompatibility and also bioactivity [7]. Moreover, products of chitosan, dibutyrylchitin [8,9,10] and polylactide [11] biodegradation show no toxicity and can be easily metabolised within human body.…”

Section: Introductionmentioning

confidence: 99%

Biopolymeric matrices based on chitosan for medical applications

et al. 2011

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Chitosan (CS) based materials in a form of composite with poly(lactic acid) (PLA) granules, films and freeze-dried scaffolds also with blend form with hydroxypropylocellulose (HPC), as well as dibutyrylchitin films were obtained. These structures are intended especially for controlled drug delivery systems, including transdermal and oral dosage forms. Excellent adhesion of biopolymer matrices to PLA microspheres or hydroxyapatite (HAp) particles was proven. The Iorder drug (ibuprofen (IBU)) release kinetics from obtained films is stated.

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