MGAT5 alters the severity of multiple sclerosis

Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice

“…This contradicts previous reports in which the absence of Mgat5 has been shown to produce autoimmune hypersensitivity, resistance to weight gain, osteoporosis, decreased muscle mass and satellite cell renewal [40], as well as an increased risk of autoimmunity and demyelination [41]. Although not directly pertinent to bone density, Mgat5 SNPs are associated with severity of multiple sclerosis in humans [42], consistent with increased sensitivity to autoimmune encephalomyelitis in Mgat5 -/-mice [43]. Glycosylation has a role in pathogenesis and the regulation of the immune system, for example in rheumatoid arthritis and diabetes [44] and glycosylation of proteins is important in the pathogenesis of autoimmune disease [45].…”

Glycans and Cancer

“…Although the real target molecules are not clear, the authors pointed out that the mechanism for which involves an Mgat5 deficiency reduces galectin-3 binding, which enhances T cell receptor mobility and clustering in response to a ligand that stimulates activation (Demetriou et al, 2001). Two markers in the MGAT5 gene were found to be associated with the severity of multiple sclerosis in a genome wide screening (Brynedal et al, 2010). These results suggest that GnT-V is involved in demyelinating disease.…”

Genetics of primary progressive multiple sclerosis

“…A genome-wide association screen identified two SNPS in MGAT5 that are associated with MS disease severity as measured by the multiple sclerosis severity score (MSSS) (Brynedal et al, 2010). MSSS scores were correlated with 11 MGAT5 SNPs in 194 patients with PPMS.…”