MgCl2 Attenuates ox-LDL-Induced Vascular Smooth Muscle–Derived Foam Cells Pyroptosis by Downregulating the TLR4/NF-κB Signaling Pathway

Xiao, He; Bai, Qingquan; Zhang, Xiaosi; Zhang, Liming

doi:10.1007/s12011-023-03585-4

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…Research by He X et al showed that MgCl 2 attenuates ox-LDL-induced pyroptosis of vascular smooth-muscle-derived foam cells through downregulation of the TLR4/NF-κB signaling pathway. The secretion of IL-1β, IL-18, and LDH was also inhibited by MgCl 2 [131].…”

Section: Magnesiummentioning

confidence: 90%

Molecular Linkage between Immune System Disorders and Atherosclerosis

Napiórkowska-Baran,

Schmidt,

Szymczak

et al. 2023

CIMB

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A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of cardiovascular diseases as well as exacerbate their course. The disorders may occur due to the presence of primary immune defects (currently known as inborn errors of immunity) and the more common secondary immune deficiencies. Secondary immune deficiencies can be caused by certain chronic conditions (such as diabetes, chronic kidney disease, obesity, autoimmune diseases, or cancer), nutritional deficiencies (including both lack of nutrients and bioactive non-nutrient compounds), and medical treatments and addictive substances. This article unravels the molecular linkage between the aforementioned immune system disorders and atherosclerosis.

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Section: Magnesiummentioning

confidence: 90%

Molecular Linkage between Immune System Disorders and Atherosclerosis

Napiórkowska-Baran,

Schmidt,

Szymczak

et al. 2023

CIMB

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“…17 In addition, although no obvious adverse effect on the proliferation of VSMCs was observed for most Mg stents alloyed with a low amount of rare earth elements (cerium, neodymium, yttrium, and ytterbium), 60 speck like protein containing a CARD, caspase-1, and gasdermin D) by downregulating the TLR4/NF-κB pathway in VSMC-derived foam cells. 71 Collectively, VSMC expansion could be restricted by the corrosion products of Mg-based DMSs in vivo, and precisely controlling their corrosion and the amassing of the released Mg 2+ would effectively tune the survival and proliferation. Mg 2+ also seemingly affects the adhesion of VSMCs in an ion dose-and exposure time-responsive manner.…”

Section: Adaptation Of Vsmcs To Dms Implantationmentioning

confidence: 99%

“…In addition, although no obvious adverse effect on the proliferation of VSMCs was observed for most Mg stents alloyed with a low amount of rare earth elements (cerium, neodymium, yttrium, and ytterbium), certain Mg–Li-(Al)-(RE) alloys that have application potentials for cardiovascular stents, became harmful to the proliferation of VSMCs after 5 days of coculture when the Mg–Li-(Al) alloys were still quite tolerable . Notably, in VSMCs 10 mM MgCl 2 was recently shown to significantly attenuate the ox-LDLs-triggered inflammation (e.g., the release of IL-1β, IL-18, and lactate dehydrogenase production) and block the pyroptosis (as indicated by the inhibition of NOD-like receptor thermal protein domain associated protein 3, apoptosis-associated speck like protein containing a CARD, caspase-1, and gasdermin D) by downregulating the TLR4/NF-κB pathway in VSMC-derived foam cells . Collectively, VSMC expansion could be restricted by the corrosion products of Mg-based DMSs in vivo , and precisely controlling their corrosion and the amassing of the released Mg 2+ would effectively tune the survival and proliferation.…”

Section: Adaptation Of Vsmcs To Dms Implantationmentioning

confidence: 99%

Adaptation of Vascular Smooth Muscle Cell to Degradable Metal Stent Implantation

Xun

Chen

2023

ACS Biomater. Sci. Eng.

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Iron-, magnesium-, or zinc-based metal vessel stents support vessel expansion at the period early after implantation and degrade away after vascular reconstruction, eliminating the side effects due to the long stay of stent implants in the body and the risks of restenosis and neoatherosclerosis. However, emerging evidence has indicated that their degradation alters the vascular microenvironment and induces adaptive responses of surrounding vessel cells, especially vascular smooth muscle cells (VSMCs). VSMCs are highly flexible cells that actively alter their phenotype in response to the stenting, similarly to what they do during all stages of atherosclerosis pathology, which significantly influences stent performance. This Review discusses how biodegradable metal stents modify vascular conditions and how VSMCs respond to various chemical, biological, and physical signals attributable to stent implantation. The focus is placed on the phenotypic adaptation of VSMCs and the clinical complications, which highlight the importance of VSMC transformation in future stent design.

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Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases

Di,

Ji,

et al. 2024

Cardiovasc Drugs Ther

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MgCl2 Attenuates ox-LDL-Induced Vascular Smooth Muscle–Derived Foam Cells Pyroptosis by Downregulating the TLR4/NF-κB Signaling Pathway

Cited by 5 publications

References 47 publications

Molecular Linkage between Immune System Disorders and Atherosclerosis

Molecular Linkage between Immune System Disorders and Atherosclerosis

Adaptation of Vascular Smooth Muscle Cell to Degradable Metal Stent Implantation

Pyroptosis of Vascular Smooth Muscle Cells as a Potential New Target for Preventing Vascular Diseases

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