mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction

Liao, Yi Han; Wang, Ya Hui; Sun, Li; Wen, Deng; Lee, Hsueh Te; Yu, Lung

doi:10.1016/j.taap.2018.09.035

Cited by 10 publications

(6 citation statements)

References 52 publications

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“…A similar role in aggression regulation was attributed to mGluR5, where inhibition of mGluR5 activity by the mGluR5 antagonists MPEP and 3-((Methyl-1,3-thiazol-4-yl)ethynyl) pyridine hydrochloride (MTEP) decreased isolation-induced aggression [127] and aggressive behavior in the resident-intruder test in mice [129], respectively. Interestingly, while MPEP decreased offensive behaviors it also increased exploration and social investigation [127], supporting studies showing that MPEP increases social investigation in models of impaired social interaction [58,75,76,77,78] (Table 1).…”

Section: Role Of Mglurs In Male Aggressive Behaviorsupporting

confidence: 68%

“…As such, MPEP normalized social investigation deficits in autistic BTBR T+tf/J mice [75] and in autistic IRSp53 knock-out mice [58] and also normalized autistic-like alterations caused by prenatal exposure to the anticonvulsant drug valproic acid in rats [76]. Pretreatment with MPEP was also successful in preventing social interaction deficits induced by a 10-day methamphetamine injections and a 10-day withdrawal regimen in mice [77] and in increasing social investigation in inbred Balb/c mice, which show impaired social interaction [78], further demonstrating its therapeutic potential. Besides normalizing the deficits in social interaction, treatment of autistic IRSp53 knock-out mice, which display enhanced NMDAR function in the hippocampus, with MPEP (which indirectly inhibits NMDA receptor function; see above) normalized NMDA receptor function and plasticity in the hippocampus and neuronal firing in the medial prefrontal cortex [55,58].…”

Section: Role Of Mglurs In Social Interactionmentioning

confidence: 99%

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The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents

Zoicas

Kornhuber

2019

IJMS

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The appropriate display of social behavior is critical for the well-being and survival of an individual. In many psychiatric disorders, including social anxiety disorder, autism spectrum disorders, depression and schizophrenia social behavior is severely impaired. Selective targeting of metabotropic glutamate receptors (mGluRs) has emerged as a novel treatment strategy for these disorders. In this review, we describe some of the behavioral paradigms used to assess different types of social behavior, such as social interaction, social memory, aggressive behavior and sexual behavior. We then focus on the effects of pharmacological modulation of mGluR1-8 on these types of social behavior. Indeed, accumulating evidence indicates beneficial effects of selective ligands of specific mGluRs in ameliorating innate or pharmacologically-induced deficits in social interaction and social memory as well as in reducing aggression in rodents. We emphasize the importance of future studies investigating the role of selective mGluR ligands on different types of social behavior to provide a better understanding of the neural mechanisms involved which, in turn, might promote the development of selective mGluR-targeted tools for the improved treatment of psychiatric disorders associated with social deficits.

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Section: Role Of Mglurs In Male Aggressive Behaviorsupporting

confidence: 68%

Section: Role Of Mglurs In Social Interactionmentioning

confidence: 99%

The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents

Zoicas

Kornhuber

2019

IJMS

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“…As reported by Liao et al, mice receiving three‐day ketamine conditioning session induced conditioned place preference (CPP), and ketamine at the conditioning dose of 5 and 10 mg/kg produced stronger magnitude of the conditioned place preference compared to that at the conditioning dose of 1 mg/kg (Liao et al, 2018). Our pre‐experiment showed that the pregnant mice given ketamine 10 mg/kg were all aborted, while those given 5 mg/kg had an abortion rate of 20%.…”

Section: Discussionmentioning

confidence: 86%

Effects of ketamine‐induced H3K9 hypoacetylation during pregnancy on cardiogenesis of mouse offspring

Quan

Zou

et al. 2023

Birth Defects Research

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Background: Prenatal exposure to adverse factors can cause congenital heart defects. Ketamine, a widely used anesthetic drug, produces several adverse reactions such as tachycardia, hypertension, and laryngospasm, especially in pediatric patients. This study aimed to detect the effects of ketamine exposure during pregnancy on the cardiogenesis of mouse offspring and the potential mechanisms.Methods: In this study, ketamine at an addictive dose (5 mg/kg) was administered to mice during early gestation to explore the epigenetic mechanism of its causing cardiac dysplasia. The cardiac morphology of the mouse offspring was observed through hematoxylin-eosin staining and transmission electron microscopy. The heart function of one-month-old neonates was detected by echocardiography. The expression of cardiomyogenesis-related genes was detected by western blot and RT-qPCR. The acetylation level of histone H3K9 at the Mlc2 promoter and its deacetylase level and activity were detected by CHIP-qPCR, RT-qPCR, and ELISA, respectively. Results: Our data revealed that ketamine exposure during pregnancy could cause cardiac enlargement, myocardial sarcomere disorganization, and decreased cardiac contractile function in mouse offspring. Moreover, ketamine reduced the expression of Myh6, Myh7, Mlc2, Mef2c, and cTnI. The histone H3K9 acetylation level at the Mlc2 promoter was down-regulated by increasing the histone deacetylase activity and HDAC3 level upon ketamine administration.Conclusions: Our work indicates that H3K9 acetylation is a vital player in cardiac dysplasia in offspring caused by prenatal ketamine exposure and HDAC3 is a key regulatory factor.

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“…To assess mice' social recognition and novelty, a custom-made three-compartment chamber (42 cm × 21 cm × 21 cm) was used (Liao et al, 2018). In brief, the test consisted of three sessions, including habituation, sociability, and social novelty preference sessions.…”

Section: Sociability and Social Novelty Preferencementioning

confidence: 99%

Effects of Septin-14 Gene Deletion on Adult Cognitive/Emotional Behavior

Chen

Wang

Liao

et al. 2022

Front. Mol. Neurosci.

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While various septin GTPases have been reported for their physiological functions, their roles in orchestrating complex cognitive/emotional functions in adult mammals remained scarcely explored. A comprehensive behavioral test battery was administered to two sexes of 12-week-old Septin-14 (SEPT14) knockout (KO) and wild-type (WT) mice. The sexually dimorphic effects of brain SEPT14 KO on inhibitory avoidance (IA) and hippocampal mGluR5 expression were noticed with greater IA latency and elevated mGluR5 level exclusively in male KO mice. Moreover, SEPT14 KO appeared to be associated with stress-provoked anxiety increase in a stress-related navigation task regardless of animals’ sexes. While male and female WT mice demonstrated comparable cell proliferation in the dorsal and ventral hippocampal dentate gyrus (DG), both sexes of SEPT14 KO mice had increased cell proliferation in the ventral DG. Finally, male and female SEPT14 KO mice displayed dampened observational fear conditioning magnitude and learning-provoked corticosterone secretion as compared to their same-sex WT mice. These results, taken together, prompt us to conclude that male, but not female, mice lacking the Septin-14 gene may exhibit increased aversive emotion-related learning and dorsal/ventral hippocampal mGluR5 expressions. Moreover, deletion of SEPT14 may be associated with elevated ventral hippocampal DG cell proliferation and stress-provoked anxiety-like behavior, while dampening vicarious fear conditioning magnitudes.

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mGluR5 upregulation and the effects of repeated methamphetamine administration and withdrawal on the rewarding efficacy of ketamine and social interaction

Cited by 10 publications

References 52 publications

The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents

The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents

Effects of ketamine‐induced H3K9 hypoacetylation during pregnancy on cardiogenesis of mouse offspring

Effects of Septin-14 Gene Deletion on Adult Cognitive/Emotional Behavior

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