MHAT-initiated redox radical cyclization of alkenylsilane enables concise syntheses of (–)-habiterpenol and (+)-2,3-epi-habiterpenol

Abstract

The concise syntheses of (–)-habiterpenol and (+)-2,3-epi-habiterpenol from (3aR)-(+)-sclareolide and 6-methoxyindanone in 11 and 12 steps, respectively, was enabled by the regioselective addition of the TMS-indenyl anion and facile stereoselective MHAT-initiated redox radical cyclization of alkenylsilane.