2002
DOI: 10.1007/s00251-001-0401-0
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MHC class I genes of the tree shrew Tupaia belangeri

Abstract: Two MHC class I cDNA sequences from the tree shrew (Tupaia belangeri), Tube-W01 and Tube-W02, have been isolated which are probably derived from classical class I genes. Expression of the tupaia class I genes was investigated in several organs, in particular the brain, in which slightly different amounts of class I transcripts are detectable in different areas. Gene tree analysis performed with Tube-W01 and Tube-W02, and including class I sequences derived from other orders, indicated that the tupaia sequences… Show more

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Cited by 14 publications
(3 citation statements)
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“…In our diagram of phylogenetic tree, Feliformia (cat), Lagomorpha (rabbit) and Caniformia (dog) as the closer specie to the tree shrew than Primates ; and tree shrew is closer to Primates than Lagomorpha (Rabbit) and Rodentia (mouse, rat, and guinea pig) those were generally used as experimental animals. This is in consistent with previous studies in tree shrew MHC class I gene [25], [26].…”
Section: Resultssupporting
confidence: 94%
“…In our diagram of phylogenetic tree, Feliformia (cat), Lagomorpha (rabbit) and Caniformia (dog) as the closer specie to the tree shrew than Primates ; and tree shrew is closer to Primates than Lagomorpha (Rabbit) and Rodentia (mouse, rat, and guinea pig) those were generally used as experimental animals. This is in consistent with previous studies in tree shrew MHC class I gene [25], [26].…”
Section: Resultssupporting
confidence: 94%
“…While different studies have provided conflicting reports on the origin of the tree shrew as well as its relationship to primates[6], [7], tree shrews have still consistently been used to develop experimental models for studying human viruses such as hepatitis A, B, C and H1N1 [8]–[12]. The success of these efforts has largely stemmed from the conceivable similarity between the immune system of the tree shrew and humans (which is not fully characterized, yet) as well as the structural evolution of genes at work in the immune system shared between tree shrews and other primates [6], [13].…”
Section: Introductionmentioning
confidence: 99%
“…The success of these efforts has largely stemmed from the conceivable similarity between the immune system of the tree shrew and humans (which is not fully characterized, yet) as well as the structural evolution of genes at work in the immune system shared between tree shrews and other primates [6], [13]. Accordingly, the next step in assessing the viability of the tree shrew model for immunological studies is to gain a more comprehensive understanding of the tree shrews' molecular and cellular immune mechanisms.…”
Section: Introductionmentioning
confidence: 99%