A numerical solution to the problem of mixed convective MHD chemically reacting flow past a vertical porous plate in the presence of thermal radiation and cross diffusion effects was studied. Instead of the commonly used conditions of constant surface temperature or constant heat flux, a convective boundary condition is employed which makes this study unique and the results more realistic and practically useful. The momentum, energy, and concentration equations derived as coupled second-order, ordinary differential equations and are solved numerically using a highly accurate and thoroughly tested finite element method. The effects of Grashof number (defined to represent a mixed convection parameter) for heat and mass transfer, Soret number, Dufour number, Viscous dissipation parameter, Chemical reaction parameter, Permeability parameter, Thermal radiation parameter and Biot number on the velocity, temperature and concentration profiles are illustrated and interpreted in physical terms. The present results agree closely with the existing results for the special cases of the problem. This close agreement lends support to the validity of the present analysis and the accuracy of the numerical computations. The paper also contains a table in which the data for the local skin friction, local Nusselt number and local Sherwood number are provided for various combination values of the parameters that govern the momentum, energy and concentration convey in the mixed boundary layer.