MICA-HLA-B haplotype diversity and linkage disequilibrium in a population of Jewish descent from Majorca (the Balearic Islands)

MICA genetic polymorphism and HLA-A,C,B,MICA and DRB1 haplotypic variation in a southern Chinese Han population: Identification of two new MICA alleles, MICA*060 and MICA*062

“…Our data revealed a high degree of MICA allelic diversification in this population. Similar to most other ethnic groups studied [11,[18][19][20][21], MI-CA*008:01 was the most prevalent allele in this population, in contrast to two tribal groups in sub-Saharan Africa [22] and the American Indian populations [23,24], where MICA*002:01, MICA* 020 or MICA*027 predominated. The two most common alleles, MICA*008:01 and MICA*010, combined accounted for about 55% of the MICA gene pool.…”

“…Significant LDs of MICA*012:01 with HLA-B*54 and HLA-B*55 were detected in the southern Chinese Han population. Relatively high frequency of MICA*012 has only been reported in very few populations, including Japanese [19], Korean [26], and a population of Jewish descent [21]. LD between MICA*012 and HLA-B*54 or HLA-B*55 was also found in those populations, indicating a common ancestral origin.…”

MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059

“…Several HLA-B-MICA haplotypes previously observed in a Japanese population were found in this population, which mainly included HLA-B*51-MICA*00901 and HLA-B*48-MICA*Del [11]. Haplotypes characteristic of Caucasian populations were also uncovered, such as HLA-B*07-MICA*00801and HLA-B*57-MICA*017 [10,16,17]. These findings are important from an anthropologic perspective, and will help determine the feasibility of international donor and recipient registries for sharing solid organs and stem cells among ethnically different populations.…”

Distribution of MICA haplotypes in a Chinese Han population

“…Several studies have demonstrated the relevance of MICA alloantibodies in acute and chronic rejection of various organs, including heart, renal, and pancreas transplants [5,6]. MICA alloantibodies mediate complement-dependent cytotoxicity in vitro, which may indicate their contribution in complement-mediated organ injury.…”