Mice lacking chromogranins exhibit increased aggressive and depression-like behaviour

Pereda, Daniel; Pardo, Marta R.; Morales, Yezer G; Domínguez, Natalia; Arnau, María Rosa; Borges, Ricardo

doi:10.1016/j.bbr.2014.09.022

Cited by 12 publications

(14 citation statements)

References 49 publications

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“…S5). Barbering is considered an abnormal repetitive behavior, and increased barbering has been observed in mouse models of anxiety and depressive-like behavior (Pereda et al, 2015). Altogether these results suggest that methyl-donor depletion induced by gut microbes alters epigenetic regulation and behavior both in parents and offspring.…”

Section: Resultsmentioning

confidence: 99%

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Romano

Campo

Kasahara

et al. 2017

Cell Host & Microbe

168

139

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SUMMARY Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here, we assessed the impact of gut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial community that lacks a single choline-utilizing enzyme. Our results indicate that choline-utilizing bacteria compete with the host for this nutrient, significantly impacting plasma and hepatic levels of methyl-donor metabolites and recapitulating biochemical signatures of choline deficiency. Mice harboring high levels of choline-consuming bacteria showed increased susceptibility to metabolic disease in the context of a high-fat diet. Furthermore, bacterially-induced reduction of methyl-donor availability influenced global DNA methylation patterns in both adult mice and their offspring and engendered behavioral alterations. Our results reveal an underappreciated effect of bacterial choline metabolism on host metabolism, epigenetics, and behavior. This work suggests that interpersonal differences in microbial metabolism should be considered when determining optimal nutrient intake requirements.

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Section: Resultsmentioning

confidence: 99%

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Romano

Campo

Kasahara

et al. 2017

Cell Host & Microbe

168

139

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“…; Pereda et al . ). Mice were backcrossed two extra generations into a C57Bl/6J background at the VU University Amsterdam.…”

Section: Methodsmentioning

confidence: 97%

“…CgA/B À/À (RRID: MGI:5919969) mice were sourced from Dr. Ricardo Borges' laboratory. Their generation and backcross to C57Bl/6J background were described previously (D ıaz- Vera et al 2012;Pereda et al 2015). Mice were backcrossed two extra generations into a C57Bl/6J background at the VU University Amsterdam.…”

Section: Animalsmentioning

confidence: 99%

Dense‐core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B

Domínguez

Weering

Borges

et al. 2017

Journal of Neurochemistry

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“…42 We observed a low fold change in our study, and interestingly an animal study reported that mice lacking SCG1 exhibited increased depressive-like behavior. 43 SCG1 was also identified as one of the 19 CFS-related proteins discovered by Baraniuk et al 30…”

Section: Discussionmentioning

confidence: 93%

Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid

et al. 2019

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Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue is generated in the brain, we aimed to investigate cerebrospinal fluid and search for molecules that participate in the pathophysiology of fatigue processes. Methods: A label-free shotgun proteomics approach was applied to analyze the cerebrospinal fluid proteome of 20 patients with primary Sjögren’s syndrome. Fatigue was measured with the fatigue visual analog scale. Results: A total of 828 proteins were identified and the 15 top discriminatory proteins between patients with high and low fatigue were selected. Among these were apolipoprotein A4, hemopexin, pigment epithelium-derived factor, secretogranin-1, secretogranin-3, selenium-binding protein 1, and complement factor B. Conclusion: Most of the discriminatory proteins have important roles in regulation of innate immunity, cellular stress defense, and/or functions in the central nervous system. These proteins and their interacting protein networks may therefore have central roles in the generation and regulation of fatigue, and the findings contribute with evidence to the concept of fatigue as a biological phenomenon signaled through specific molecular pathways.

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Mice lacking chromogranins exhibit increased aggressive and depression-like behaviour

Cited by 12 publications

References 49 publications

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Dense‐core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B

Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid

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