Micellar liquid chromatography of terephthalic acid impurities

Richardson, Ashley E.; McPherson, Shakeela D.; Fasciano, Jennifer M.; Pauls, R. E.; Danielson, Neil D.

doi:10.1016/j.chroma.2017.02.039

Cited by 10 publications

(2 citation statements)

References 36 publications

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“…These results indicate that this mobile phase improves the penetration of the solutes and has a minor interaction with the silanol chains, which may be due to a greater association between the ionic monomer surfactant and the alkyl bonded to the silica stationary phase . The surfactant monolayer was thus partially coated in the stationary phase, resulting in short retention times . In these conditions, the submicellar mobile phase of SDS (0.007 M SDS/ACN 50:50 v/v) was selected to analyze low concentrations of NAP in tissues such as the brain.…”

Section: Resultsmentioning

confidence: 99%

Submicellar liquid chromatography with fluorescence detection improves the analysis of naproxen in plasma and brain tissue

García-Herrero

Torrado-Salmerón

García-Rodríguez

et al. 2019

J of Separation Science

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Rapid, simple, and sensitive submicellar liquid chromatography with fluorescence detection was developed and validated to quantify naproxen in plasma and brain samples after oral administration of Naproxen formulations. The method used tramadol as an internal standard. Different submicellar mobile phases with organic phases ranging from 40 to 60% were studied to improve the native fluorescence of the Naproxen and decrease retention times. Separation was done in a Zorbax SB C8 column (250 × 4.6 mm, 5 μm) with a mobile phase containing acidic 0.007 M sodium dodecyl sulfate/acetonitrile (50:50, v/v) at a flow rate of 1 mL/min. Detection was performed with an excitation wavelength of 280 nm and emission of 310 nm and 360 nm for internal standard and Naproxen, respectively. The method was validated by International Conference of Harmonization standards. The method is specific, accurate, and precise (relative standard deviation <3%). Limits of detection and quantification were 0.08 and 0.25 μg/mL, respectively, for biological samples. This method was applied to analyze brain/plasma ratios in mice that had received oral administrations of Naproxen micellar formulations containing 10% w/w of sodium dodecyl sulfate, Cremophor RH 40, or Tween 80. The sodium dodecyl sulfate micelles were faster and more widely distributed in the mouse brains.

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Section: Resultsmentioning

confidence: 99%

Submicellar liquid chromatography with fluorescence detection improves the analysis of naproxen in plasma and brain tissue

García-Herrero

Torrado-Salmerón

García-Rodríguez

et al. 2019

J of Separation Science

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“…[11]. Various mono-, di-, and tri-carboxylated aromatics, and eight impurities that were formed in the synthesis of terephthalic acid, were separated isocratically on a C18 column in about 17 min using 1% SDS adjusted to pH 3 [12]. A recent study involving the separation of the same terephthalic acid impurities, but using simply a C18 column coated with the nonionic surfactant polyoxyethylene (20), sorbitan monolaurate (Tween 20) and present at 0.001% or less in the isocratic mobile phase, was possible in under 20 min [13].…”

Section: Introductionmentioning

confidence: 99%

Ultra-High-Performance Micellar Liquid Chromatography Comparing Tween 20 and Tween 40 for the Determination of Hydroxycinnamic Acids

Ali

Danielson

2022

Separations

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A simple and green ultra-high-performance micellar liquid chromatography (MLC) method was developed here, comparing Tween 20 and Tween 40 for the first time as the only mobile phase modifiers with a C18 column. Its application to the separation of nine hydroxycinnamic acid (HCA) derivatives (cinnamic, caffeic, ferulic, sinapic, o-, m-, p-coumaric, 3,4-dihydroxyhydrocinnamic, and chlorogenic acids) was made, due to their importance as antioxidants in a variety of natural beverages such as wine and coffee. The optimal conditions of 45 °C temperature (T), 1% surfactant in the mobile phase, and pH control with 2.5 mM sulfuric acid were determined and used to elucidate the analytical figures of merit. Although the effect of these conditions was insignificant between the two surfactants, the nine-component HCA mixture was separated faster—in about 15 min—and with less peak tailing using Tween 20 than with Tween 40. The linearity of the Van’t Hoff (lnk versus 1/T) plots was evident for Tween 20, indicating a single retention mechanism—but less so for Tween 40. The equilibrium constants of the analytes with the micelles and the stationary phase were calculated. The developed method was successfully used to analyze organic red wine, spiked organic red wine, and green coffee diet pills. The percent recoveries of the nine HCA compounds spiked in the organic red wine ranged from 90% to 107%. The green coffee extract diet pills showed the presence of a significant amount of chlorogenic acid.

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Green Chromatography and Related Techniques

Aly¹,

Górecki²

2019

Green Chemistry and Sustainable Technology

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Micellar liquid chromatography of terephthalic acid impurities

Cited by 10 publications

References 36 publications

Submicellar liquid chromatography with fluorescence detection improves the analysis of naproxen in plasma and brain tissue

Submicellar liquid chromatography with fluorescence detection improves the analysis of naproxen in plasma and brain tissue

Ultra-High-Performance Micellar Liquid Chromatography Comparing Tween 20 and Tween 40 for the Determination of Hydroxycinnamic Acids

Green Chromatography and Related Techniques

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