Micelles Based on Lysine, Histidine, or Arginine: Designing Structures for Enhanced Drug Delivery

Li, Jingchi; Liu, Rong; Chen, Xin; He, Mian; Zhang, Yi; Chen, Shuyi

doi:10.3389/fbioe.2021.744657

Cited by 15 publications

(15 citation statements)

References 118 publications

(166 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dialysis membranes were placed in centrifuge tubes including 25 mL of PBS with different pH values, and the samples were shaken at 120 rpm and 37 °C. At given times (1,2,3,4,5,6,7,8,24,48,72, and 96 h), 1 mL of the external buffer was taken at regular intervals for analysis, and 1 mL of the fresh medium was added. The DOX release at each time point was calculated based on the standard curve drawn from the absorbance of different concentrations of DOX at an excitation wavelength of 485 nm obtained using the fluorescence spectrophotometer, and the drug release curves at different pH values were plotted.…”

Section: Determination Of Critical Micelle Concentrationmentioning

confidence: 99%

Multifunctional Dendritic Au@SPP@DOX Nanoparticles Integrating Chemotherapy and Low-Dose Radiotherapy for Enhanced Anticancer Activity

Zhang

Yang

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

Combined chemoradiotherapy can improve antitumor efficiency and reduce the side effects of monotherapy. In this study, we aimed to construct dendritic peptide-based multifunctional nanoparticles (Au@SPP@DOX) for a prolonged circulation time, enhanced cellular uptake, and targeted cancer therapy. Amphiphilic micelle PEG-polylysine-SA (SPP) is composed of polylysine combined with hydrophilic poly(ethylene glycol) (PEG) and hydrophobic stearic acid (SA). Doxorubicin (DOX) is loaded via the hydrophilic−hydrophobic interaction of SPP, and gold nanoparticles (AuNPs) are loaded via the electrostatic interaction with SPP. Au@SPP@DOX showed good biocompatibility and could be successfully accumulated at tumor sites through the enhanced permeability and retention (EPR) effect. Then, lysosomes could be ruptured due to the proton sponge effect. DOX became protonated in response to tumor extracellular acidity and was then released from SPP. Under the action of low-dose radiation, Au@SPP@DOX could promote the production of reactive oxygen species (ROS), increase mitochondrial dysfunction, block cell division, and ultimately promote tumor cell apoptosis to achieve a better antitumor effect. This study highlighted the benefit of chemoradiotherapy and suggested that Au@SPP@DOX might serve as a high-efficiency codelivery system for cancer combination therapy in the future.

show abstract

Section: Determination Of Critical Micelle Concentrationmentioning

confidence: 99%

Multifunctional Dendritic Au@SPP@DOX Nanoparticles Integrating Chemotherapy and Low-Dose Radiotherapy for Enhanced Anticancer Activity

Zhang

Yang

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Furthermore, surface modification of micelles, for instance, with phenyboronic acid promotes selectivity toward tumor cells and enhances the tumor‐suppressor activity of DOX. 238 , 239 , 240 , 241 , 242 …”

Section: Nanostructures Of Chitosan‐doxorubicinmentioning

confidence: 99%

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Ashrafizadeh

Hushmandi

Mirzaei

et al. 2022

Bioengineering & Transla Med

View full text Add to dashboard Cite

Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation.

show abstract

“…The self-assembly of amphiphilic polymers into micelles makes them excellent gene carriers. Amphiphilic cationic polymers such as polylysine (PLL) [96], PEI [97,98], polyamidoamine (PAMAM) [99], and polydimethylaminoethyl methacrylate (PDMAEMA) [100,101] are commonly used to construct cationic micelles [102,103].…”

Section: Micellesmentioning

confidence: 99%

Nonviral delivery systems for antisense oligonucleotide therapeutics

Huang

Hao

et al. 2022

Biomater Res

View full text Add to dashboard Cite

Antisense oligonucleotides (ASOs) are an important tool for the treatment of many genetic disorders. However, similar to other gene drugs, vectors are often required to protect them from degradation and clearance, and to accomplish their transport in vivo. Compared with viral vectors, artificial nonviral nanoparticles have a variety of design, synthesis, and formulation possibilities that can be selected to accomplish protection and delivery for specific applications, and they have served critical therapeutic purposes in animal model research and clinical applications, allowing safe and efficient gene delivery processes into the target cells. We believe that as new ASO drugs develop, the exploration for corresponding nonviral vectors is inevitable. Intensive development of nonviral vectors with improved delivery strategies based on specific targets can continue to expand the value of ASO therapeutic approaches. Here, we provide an overview of current nonviral delivery strategies, including ASOs modifications, action mechanisms, and multi-carrier methods, which aim to address the irreplaceable role of nonviral vectors in the progressive development of ASOs delivery.

show abstract

Micelles Based on Lysine, Histidine, or Arginine: Designing Structures for Enhanced Drug Delivery

Cited by 15 publications

References 118 publications

Multifunctional Dendritic Au@SPP@DOX Nanoparticles Integrating Chemotherapy and Low-Dose Radiotherapy for Enhanced Anticancer Activity

Multifunctional Dendritic Au@SPP@DOX Nanoparticles Integrating Chemotherapy and Low-Dose Radiotherapy for Enhanced Anticancer Activity

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Nonviral delivery systems for antisense oligonucleotide therapeutics

Contact Info

Product

Resources

About