Micellization parameters (number average, aggregation number and critical micellar concentration) of bile salt 3 and 7 ethylidene derivatives: Role of the steroidal skeleton II

Poša, Mihalj; Bjedov, Srđan; Škorić, Dušan; Sakač, Marija N.

doi:10.1016/j.bbagen.2015.03.010

Cited by 17 publications

(7 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No break corresponding to the premicellar formation is observed in the conductivity curve (r vs m NaCA ), indicating almost complete counterion dissociation in the pre-micelle association. We see this as expected and reasonable, as in this region the aggregation number must be very small, due to the rigidity of the steroid skeleton [53].…”

Section: The Micellization Of the Mixed Naca/sds In Aqueous Solutionfmentioning

confidence: 54%

Interaction between a hydrophobic rigid face and a flexible alkyl tail: Thermodynamics of self-assembling of sodium cholate and SDS

Bai

Sheng

Wang

et al. 2016

The Journal of Chemical Thermodynamics

View full text Add to dashboard Cite

Section: The Micellization Of the Mixed Naca/sds In Aqueous Solutionfmentioning

confidence: 54%

Interaction between a hydrophobic rigid face and a flexible alkyl tail: Thermodynamics of self-assembling of sodium cholate and SDS

Bai

Sheng

Wang

et al. 2016

The Journal of Chemical Thermodynamics

View full text Add to dashboard Cite

“…The peaks displayed an increase pattern as the concentration of DCMCs was increased. The results suggest that hydrogen bond was formed with water molecules from the hydration layer on the COO -group of each amphiphilic chitosan derivatives chain [22]. Furthermore, the association of the hydrophobic group in OCMCs, DCMCs and DACMCs around pyrene molecules had enhanced the intensity of peak I272 [19].…”

Section: Critical Micelles Concentration (Cmc)mentioning

confidence: 69%

Amphiphilic chitosan derivatives as carrier agents for rotenone

Kamari

Aljafree

2017

AIP Conference Proceedings

View full text Add to dashboard Cite

Abstract.In the present study, the feasibility of amphiphilic chitosan derivatives, namely oleoyl carboxymethyl chitosan (OCMCs), N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) and deoxycholic acid carboxymethyl chitosan (DACMCs) as carrier agents for rotenone in water-insoluble pesticide formulations was investigated. Fourier Transform Infrared (FTIR) Spectrometer, CHN-O Elemental Analyser (CHN-O) and Transmission Electron Microscope (TEM) were used to characterise amphiphilic chitosan derivatives. The critical micelle concentration (CMC) of amphiphilic chitosan derivatives was determined using a Fluorescence Spectrometer. A High Performance Liquid Chromatography (HPLC) was used to determine the ability of OCMCs, DCMCs and DACMCs to load and release rotenone in an in vitro system. Based on TEM analysis, results have shown that amphiphilic chitosan derivatives formed self-assembly and exhibited spherical shape. The CMC values determined for OCMCs, DCMCs and DACMCs were 0.093, 0.098 and 0.468 mg/mL, respectively. The encapsulation efficiency (EE) values for the materials were more than 97.0%, meanwhile the loading capacity (LC) values were greater than 0.90%. OCMCs, DCMCs and DACMCs micelles exhibited an excellent ability to control the release of rotenone, of which 90.0% of rotenone was released within 40 to 52 h. In conclusion, OCMCs, DCMCs and DACMCs possess several key features to act as effective carrier agents for rotenone. Overall, amphiphilic chitosan derivatives produced in this study were successfully increased the solubility of rotenone by 49.0 times higher than free rotenone.

show abstract

“…Primary aggregates which are spherical or slightly oblate in shape, are created by the hydrophobic interaction [ 53 , 54 ], and those aggregates may interact with hydrogen bonds when linked together by the outwardly directed hydrophilic part of the ion constituents, result in the formation of various, complex shapes of secondary micelles such as flattened or rod-like objects known as secondary aggregates [ 40 ]. The creation process of the primary and secondary micelles was confirmed by the molecular dynamics simulations [ 40 , 42 , 55 , 56 ]. The mechanism of the formation of the micelles was noticed to be different for deoxycholate (di-hydroxy BS) and cholate (tri-hydroxy BS) [ 40 ] specifically a micelle created by the cholate remains a dimer even at 30 mM, which are linked by H-bonds, while the deoxycholate creates primary micelles by hydrophobic interaction and the secondary micelles by hydrogen bonding [ 40 ].…”

Section: Resultsmentioning

confidence: 87%

Importance of Conjugation of the Bile Salt on the Mechanism of Lipolysis

Łozińska

Jungnickel

2021

Molecules

View full text Add to dashboard Cite

We aim to advance the discussion on the significance of the conjugation of bile salts (BS) in our organism. We hypothesize that conjugation influences the rate of lipolysis. Since the rate of lipolysis is a compound parameter, we compare the effect of conjugation on four surface parameters, which contribute to the rate. Since deconjugation is due to gut microbiota, we hypothesize that microbiota may affect the rate of lipolysis. A meta-analysis of literature data of critical micelle concentration, β, aggregation number, and molar solubilization ratio has been performed for the first time. In addition, critical micelle concentration (CMC), interfacial tension, and lipolysis rate measurements were performed. It was found that the unconjugated BS in mixed micelles increases the antagonism between the BS, therefore, increasing the CMC. This correlated with the effect of unconjugated BS on the solubilization capacity of mixed micelles. The collected literature information indicates that the role of the BS and its conjugation in our organism is a key factor influencing the functioning of our organism, where too high levels of unconjugated BS may lead to malabsorption of fat-soluble nutrients. The experimental lipolysis results irrevocably showed that conjugation is a significant factor influencing the rate.

show abstract

Micellization parameters (number average, aggregation number and critical micellar concentration) of bile salt 3 and 7 ethylidene derivatives: Role of the steroidal skeleton II

Cited by 17 publications

References 55 publications

Interaction between a hydrophobic rigid face and a flexible alkyl tail: Thermodynamics of self-assembling of sodium cholate and SDS

Interaction between a hydrophobic rigid face and a flexible alkyl tail: Thermodynamics of self-assembling of sodium cholate and SDS

Amphiphilic chitosan derivatives as carrier agents for rotenone

Importance of Conjugation of the Bile Salt on the Mechanism of Lipolysis

Contact Info

Product

Resources

About