Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices

Betancourt, Tania; Brannon-Peppas, Lisa

doi:10.2147/nano.2006.1.4.483

Cited by 140 publications

(80 citation statements)

References 61 publications

(113 reference statements)

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“…In this depicted microchip, a thin gold membrane, (Santini et al, 2000b;Betancourt & Brannon-Peppas, 2006;Sharma et al, 2006) capped drug reservoirs in silicon (Stevenson et al, 2006) serves as an anode in an electrochemical reaction (Dario et al, 2000;Santini et al, 2000b). Furthermore, the purpose for developing a microfabricated device was to avoid the moving parts, but it was capable to store and release multiple chemical entities.…”

Section: Implantable Controlled Release Microchips: Design and Componmentioning

confidence: 99%

“…These microchip devices are now being commercially developed by the company by a Bedford, MA, called MicroCHIPS Technology (Webb, 2004;Gardner, 2006;Sharma et al, 2006;Staples et al, 2006). This company took its first step toward proving such a device is possible in March 2006, when results of the first animal test of an implantable drug-delivery system were published (Betancourt & Brannon-Peppas, 2006;Jonietz, 2006). Kim et al (2007) have done the first investigational application with these microchips in chemotherapy.…”

Section: Implantable Controlled Release Microchips: Design and Componmentioning

confidence: 99%

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Implantable microchip: the futuristic controlled drug delivery system

2014

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There is no doubt that controlled and pulsatile drug delivery system is an important challenge in medicine over the conventional drug delivery system in case of therapeutic efficacy. However, the conventional drug delivery systems often offer a limited by their inability to drug delivery which consists of systemic toxicity, narrow therapeutic window, complex dosing schedule for long term treatment etc. Therefore, there has been a search for the drug delivery system that exhibit broad enhancing activity for more drugs with less complication. More recently, some elegant study has noted that, a new type of micro-electrochemical system or MEMS-based drug delivery systems called microchip has been improved to overcome the problems related to conventional drug delivery. Moreover, micro-fabrication technology has enabled to develop the implantable controlled released microchip devices with improved drug administration and patient compliance. In this article, we have presented an overview of the investigations on the feasibility and application of microchip as an advanced drug delivery system. Commercial manufacturing materials and methods, related other research works and current advancement of the microchips for controlled drug delivery have also been summarized.

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Section: Implantable Controlled Release Microchips: Design and Componmentioning

confidence: 99%

Section: Implantable Controlled Release Microchips: Design and Componmentioning

confidence: 99%

Implantable microchip: the futuristic controlled drug delivery system

2014

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“…5 Moreover, the fabrications of these biosensors are facile and can be scaled down without significantly affecting their performance. 6,7 Urea biosensors are based on the urease (Urs) enzyme, which catalyzes the hydrolysis of urea generating ammonium and bicarbonate ions. These species influences the pH of the surrounding environment.…”

Section: Introductionmentioning

confidence: 99%

Amperometric urea biosensors based on sulfonated graphene/polyaniline nanocomposite

An¹,

Yoon²,

Das³

2015

IJN

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An electrochemical biosensor based on sulfonated graphene/polyaniline nanocomposite was developed for urea analysis. Oxidative polymerization of aniline in the presence of sulfonated graphene oxide was carried out by electrochemical methods in an aqueous environment. The structural properties of the nanocomposite were characterized by Fourier-transform infrared, Raman spectroscopy, X-ray photoelectron spectroscopy, and scanning electron microscopy techniques. The urease enzyme-immobilized sulfonated graphene/polyaniline nanocomposite film showed impressive performance in the electroanalytical detection of urea with a detection limit of 0.050 mM and a sensitivity of 0.85 (μA · cm −2 ·mM −1 . The biosensor achieved a broad linear range of detection (0.12–12.3 mM) with a notable response time of approximately 5 seconds. Moreover, the fabricated biosensor retained 81% of its initial activity (based on sensitivity) after 15 days of storage at 4°C. The ease of fabrication coupled with the low cost and good electrochemical performance of this system holds potential for the development of solid-state biosensors for urea detection.

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“…7,8 Through the integration of multiple processes onto a single platform, complete cellular and molecular assays can be performed on-chip, thus negating the need for dedicated laboratories and lab-based infrastructure; such micrototal analysis systems can reduce the complexity as well as improve the efficacy of analytical assays. 9,10 By leveraging traditional fabrication methods on glass and silicon substrates including standard photolithography, direct etching, and thin film deposition, complex LOC devices have been fabricated to perform such processes as immunoassays, polymerase chain reaction, and single cell analysis.…”

Section: Introductionmentioning

confidence: 99%

“…8 Specifically, the ability to mold PDMS from glass and silicon substrates and bond PDMS to glass slides to form complete microfluidic channels reduced the need for expensive tooling costs associated with previous LOC devices. Although this process alleviated some of the expenses of microfabrication, glass and silicon masters still require photolithography.…”

Section: Introductionmentioning

confidence: 99%

Shrink-film microfluidic education modules: Complete devices within minutes

et al. 2011

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As advances in microfluidics continue to make contributions to diagnostics and life sciences, broader awareness of this expanding field becomes necessary. By leveraging low-cost microfabrication techniques that require no capital equipment or infrastructure, simple, accessible, and effective educational modules can be made available for a broad range of educational needs from middle school demonstrations to college laboratory classes. These modules demonstrate key microfluidic concepts such as diffusion and separation as well as "laboratory on-chip" applications including chemical reactions and biological assays. These modules are intended to provide an interdisciplinary hands-on experience, including chip design, fabrication of functional devices, and experiments at the microscale. Consequently, students will be able to conceptualize physics at small scales, gain experience in computer-aided design and microfabrication, and perform experiments-all in the context of addressing real-world challenges by making their own lab-on-chip devices.

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Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices

Cited by 140 publications

References 61 publications

Implantable microchip: the futuristic controlled drug delivery system

Implantable microchip: the futuristic controlled drug delivery system

Amperometric urea biosensors based on sulfonated graphene/polyaniline nanocomposite

Shrink-film microfluidic education modules: Complete devices within minutes

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