Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis

Zhang, Z.-M.; Li, Z.-C.; Jiang, Lei; Jiang, Sheng‐Dan; Dai, L.-Y.

doi:10.1007/s00198-009-1071-2

Cited by 99 publications

(97 citation statements)

References 38 publications

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“…These findings fit previous observations [7-9, 14, 30, 31] and highlight the role of the trabecular component as an additional protective factor against fracture [32]. In fact, by dissecting the influence on the mechanical properties of individual structural factors, better preserved trabecular features were found to increase the ability to withstand stress in OA, offering protection against femoral fracture [9,30]. Consistently, small increments in trabecular thickness have been associated with disproportionately large gains in bone strength [33].…”

Section: Discussionsupporting

confidence: 91%

“…Accordingly, higher bone mass density (BMD) was previously found in the femoral necks of twins with OA compared to their co-twins without OA [6]. Accumulating evidence suggests that patients with primary OA and OP represent morphologically different populations with characteristic trabecular bone architecture responsible for their inverse relationships [7][8][9]. However, the relationship between these two common, age-related disorders remains controversial [10], as it is much more complex than commonly believed.…”

Section: Introductionmentioning

confidence: 99%

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Comparative high-resolution pQCT analysis of femoral neck indicates different bone mass distribution in osteoporosis and osteoarthritis

Rubinacci¹,

Tresoldi²,

Scalco³

et al. 2011

Osteoporos Int

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Comparative high-resolution pQCT analysis of femoral neck indicates different bone mass distribution in osteoporosis and osteoarthritis

Rubinacci¹,

Tresoldi²,

Scalco³

et al. 2011

Osteoporos Int

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“…Our results on trabecular bone structure of the proximal humerus are comparable to the data reported in different in vitro and in vivo studies of other body regions [25][26][27][28][29]. Subchondral bone harvested in hip joints with osteoarthritis showed more than about twice the BV/TV and Tb.N of our bone cores [26,28].…”

Section: Discussionsupporting

confidence: 89%

Influence of trabecular microstructure and cortical index on the complexity of proximal humeral fractures

Osterhoff

Diederichs

Tami

et al. 2011

Arch Orthop Trauma Surg

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“…Various methods for filtering and measuring image features have been described before [21,[23][24][25][26][27][28][29][30][31][32]. Similar image features are current in studies on osteoporosis and bone structure [33][34][35][36][37][38][39].…”

Section: Image Processingmentioning

confidence: 99%

Sparseness of the trabecular pattern on dental radiographs: visual assessment compared with semi-automated measurements

Geraets¹,

Lindh²,

Verheij³

2012

The British Journal of Radiology

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Objective: In diagnostic imaging; human perception is the most prominent, yet least studied, source of error. A better understanding of image perception will help to improve diagnostic performance. This study focuses on the perception of coarseness of trabecular patterns on dental radiographs. Comparison of human vision with machine vision should yield knowledge on human perception. Method: In a study on identifying osteoporotic patients, dental radiographs were made from 505 post-menopausal women aged 45-70 years. Intra-oral radiographs of the lower and upper jaws were made. Five observers graded the trabecular pattern as dense, sparse or mixed. The five gradings were combined into a single averaged observer score per jaw. The radiographs were scanned and a region of interest (ROI) was indicated on each. The ROIs were processed with image analysis software measuring 25 image features. Pearson correlation and multiple linear regression were used to compare the averaged observer score with the image features. Results: 14 image features correlated significantly with the observer judgement for both jaws. The strongest correlation was found for the average grey value in the ROI. Other features, describing that osteoporotic patients have fewer but bigger marrow spaces than controls, correlated less with the sparseness of the trabecular pattern than a rather crude measure for structure such as the average grey value. Conclusion: Human perception of the sparseness of trabecular patterns is based more on average grey values of the ROI than on geometric details within the ROI.

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Micro-CT and mechanical evaluation of subchondral trabecular bone structure between postmenopausal women with osteoarthritis and osteoporosis

Abstract: We observed the difference in microstructure between postmenopausal women with OA and OP, which might relate to the opposite bone defects in OA and OP. BV/TV might play an important role in mechanical properties of the subchondral bone in either OA or OP.

Cited by 99 publications

References 38 publications

Comparative high-resolution pQCT analysis of femoral neck indicates different bone mass distribution in osteoporosis and osteoarthritis

Comparative high-resolution pQCT analysis of femoral neck indicates different bone mass distribution in osteoporosis and osteoarthritis

Influence of trabecular microstructure and cortical index on the complexity of proximal humeral fractures

Sparseness of the trabecular pattern on dental radiographs: visual assessment compared with semi-automated measurements

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