This work presents the design of a front-end MEMS piezoresistive pressure sensor readout circuit along with a drug actuator model based on TSMC 0.18 lm CMOS technology. The overall system finds application in implantable systems based on micro-pressure sensing and actuation such as the closed loop automatic micturition chip. The system consists of high performance and ultra-low noise chopper stabilized differential amplifier front-end, a digitally programmable threshold generator and window comparator circuit for setting up the pressure thresholds for urination, and an actuator model that simulates drug delivery for micturition, overactive bladder control, and bladder closure. The system also has a novel core circuit enable for power savings mode. The corresponding sub-circuits have been designed to operate in low power that is suitable for implantation and be powered by energy harvesters.